ReviewTemperature (Austin, Tex.)
Temperature and toxic Tau in Alzheimer's disease: new insights.
Review in Temperature (Austin, Tex.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- Perceived indoor thermal environment and depressive symptoms among older adults in the Japan Gerontological Evaluation Study.Scientific reports · 2025Article
- Temperature-Dependent Aggregation of Tau Protein Is Attenuated by Native PLGA Nanoparticles Under in vitro Conditions.International journal of nanomedicine · 2025Article
- Article
- Thermotherapy has Sexually Dimorphic Responses in APP/PS1 Mice.bioRxiv : the preprint server for biology · 2024Article
- Ambient temperatures associated with reduced cognitive function in older adults in China.Scientific reports · 2023Article
- Chronic, Mild Hypothermic Environmental Temperature Does Not Ameliorate Cognitive Deficits in an Alzheimer's Disease Mouse.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Predictors of Conversion to Dementia in Patients With Mild Cognitive Impairment: The Role of Low Body Temperature.Journal of clinical medicine research · 2023Article
- Deletion of UCP1 in Tg2576 Mice Increases Body Temperature and Exacerbates Alzheimer's Disease-Related Pathologies.International journal of molecular sciences · 2023Article
- Altered Microcirculation in Alzheimer's Disease Assessed by Machine Learning Applied to Functional Thermal Imaging Data.Bioengineering (Basel, Switzerland) · 2022Article
- Article
- Sustained high body temperature exacerbates cognitive function and Alzheimer's disease-related pathologies.Scientific reports · 2022Article
- The importance of body core temperature evaluation in balneotherapy.International journal of biometeorology · 2022Review
- Body Temperature Is Associated With Cognitive Performance in Older Adults With and Without Mild Cognitive Impairment: A Cross-sectional Analysis.Frontiers in aging neuroscience · 2021Article
- Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- BAG2 structure, function and involvement in disease.Cellular & molecular biology letters · 2016Review
- Biotic/Abiotic Stress-Driven Alzheimer's Disease.Frontiers in cellular neuroscience · 2016Article
- Evaluation of dexmedetomidine anesthesia-related temperature changes: preliminary retrospective observational study.Brazilian journal of anesthesiology (Elsevier)Observational
- Brazil: What country is this?Temperature (Austin, Tex.)Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease (AD), the most common dementia in the elderly, is characterized by cognitive impairment and severe autonomic symptoms such as disturbance in core body temperature (Tc), which may be predictors or early events in AD onset. Inclusions of phosphorylated Tau (p-Tau) are a hallmark of AD and other neurodegenerative disorders called "Tauopathies." Animal and human studies show that anesthesia augments p-Tau levels through reduction of Tc, with implications for AD. Additionally, hypothermia impairs memory and cognitive function. The molecular networks related to Tc that are associated with AD remain poorly characterized. Under physiological conditions, Tau binds microtubules, promoting their assembly and stability. The dynamically regulated Tau-microtubule interaction plays an important role in structural remodeling of the cytoskeleton, having important functions in neuronal plasticity and memory in the hippocampus. Hypothermia-induced increases in p-Tau levels are significant, with an 80% increase for each degree Celsius below normothermic conditions. Although the effects of temperature on Tau phosphorylation are evident, its effects on p-Tau degradation remain poorly understoodWe review information concerning the mechanisms of Tau regulation of neuron plasticity via its effects on microtubule dynamics, with focus on pathways regulating the abundance of phosphorylated Tau species. We highlight the effects of temperature on molecular mechanisms influencing the development of Tau-related diseases. Specifically, we argue that cold might preferentially affects central nervous system structures that are highly reliant upon plasticity, such as the hippocampus, and that the effect of cold on Tau phosphorylation may constitute a pathology-initiating trigger leading to neurodegeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.