ReviewTemperature (Austin, Tex.)
Neural circuit for psychological stress-induced hyperthermia.
Review in Temperature (Austin, Tex.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Treatment of Early-Onset Specified and Unspecified Bipolar Disorders: A Systematic Review and Strategies for Identifying and Managing a Thermally Dysregulated Subtype in Children.Acta psychiatrica Scandinavica · 2025Pooled it
- Prolactin receptor signalling contributes to the attenuation of stress-induced hyperthermia during pregnancy.Journal of neuroendocrinology · 2026Article
- Limb restraint induces a rapid and profound decrease in core body temperature associated with the stress response in mice.PNAS nexus · 2026Article
- Sarcolipin-SERCA uncoupling as a plausible heat source for sustaining fever.Frontiers in physiology · 2026Article
- Thermal imaging in biomedical research: a non-invasive technology for animal models.Frontiers in veterinary science · 2025Review
- Mice with deficiency in Pcdh15, a gene associated with bipolar disorders, exhibit significantly elevated diurnal amplitudes of locomotion and body temperature.Translational psychiatry · 2024Article
- Behavioural and physiological responses to stressors in sheep with temperament classified by genotype or phenotype.Scientific reports · 2024Article
- Review
- Thermal Balance in Male Water Buffaloes Transported by Long and Short Journeys.Animals : an open access journal from MDPI · 2023Article
- It's cool to be stressed: body surface temperatures track sympathetic nervous system activation during acute stress.The Journal of experimental biology · 2023Article
- A sex-specific thermogenic neurocircuit induced by predator smell recruiting cholecystokinin neurons in the dorsomedial hypothalamus.Nature communications · 2023Article
- Infrared thermography for non-invasive measurement of social inequality aversion in rodents and potential usefulness for future animal-friendly studies.Frontiers in behavioral neuroscience · 2023Review
- Assessment of thermal changes in water buffalo mobilized from the paddock and transported by short journeys.Frontiers in veterinary science · 2023Article
- In vivo imaging of brown adipose tissue vasculature reactivity during adrenergic stimulation of non-shivering thermogenesis in mice.Scientific reports · 2022Article
- Altered skeletal muscle sarco-endoplasmic reticulum CaAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Is It Useful to Determine the Temperature of Children for COVID-19 Screening in the Dental Setting?Journal of clinical medicine · 2022Article
- A hypothalamomedullary network for physiological responses to environmental stresses.Nature reviews. Neuroscience · 2022Review
- Centrally Projecting Edinger-Westphal Nucleus in the Control of Sympathetic Outflow and Energy Homeostasis.Brain sciences · 2021Review
- Learned Immobility Produces Enduring Impairment of the HPA Axis Reactivity in Mice without Replicating the Broad Spectrum of Depressive-Like Phenotype.International journal of molecular sciences · 2021Article
- Infrared Thermography Reveals Sex-Specific Responses to Stress in Mice.Frontiers in behavioral neuroscience · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Psychological stress-induced hyperthermia (PSH) is a basic physiological stress response to increase physical performances to defend homeostasis and life from stressors, such as natural enemies. However, excessive and long-lasting stressors can lead to chronic hyperthermia, particularly recognized in humans as a psychosomatic symptom called "psychogenic fever." The sympathetic and neuroendocrine responses that can contribute to PSH include brown adipose tissue (BAT) thermogenesis, cutaneous vasoconstriction, tachycardia and glucocorticoid secretion. Research on the central circuits underlying these stress responses has recently revealed several fundamental circuit mechanisms including hypothalamomedullary pathways driving the sympathetic stress responses. Psychological stress activates a monosynaptic glutamatergic excitatory neurotransmission from the dorsomedial hypothalamus (DMH) to sympathetic premotor neurons in the rostral medullary raphe region (rMR) to drive BAT thermogenesis and tachycardia, leading to the development of PSH. This glutamatergic neurotransmission could be potentiated by orexin neurons in the lateral hypothalamus through their projections to the rMR. Psychological stress also activates another monosynaptic pathway from the DMH to the paraventricular hypothalamic nucleus to stimulate the hypothalamo-pituitary-adrenal axis for the secretion of glucocorticoids. PSH is independent from the prostaglandin-mediated trigger mechanism for inflammation-induced fever, and several forebrain regions are considered to provide stress-driven inputs to the DMH to activate the sympathetic- and neuroendocrine-driving neurons. The circuit mechanism of PSH based on animal experiments would be relevant to understandings of the etiology of psychogenic fever in humans. This review describes the current understandings of the central circuit mechanism of PSH with recent important progress in research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.