Evidence map›Paper›PMID 27227022›Full record

ReviewTemperature (Austin, Tex.)

TRP ion channels in thermosensation, thermoregulation and metabolism.

Hong Wang, Jan Siemens

Open access · bronzeAbstract readReview
In one paragraph

Review in Temperature (Austin, Tex.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 149 citations in OpenAlex.

  1. Hesperetin-7-Nutrients · 2023
    Trial
  2. Effects of Thermal Stress on Growth and Reproduction ofAnimals : an open access journal from MDPI · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. TRPV3 in skin thermosensation and temperature responses.The journal of physiological sciences : JPS · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Thermosensing ability of TRPC5: current knowledge and unsettled questions.The journal of physiological sciences : JPS · 2024
    Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

Hong WangDepartment of Pharmacology; University of Heidelberg ; Heidelberg, Germany.
Jan SiemensDepartment of Pharmacology; University of Heidelberg ; Heidelberg, Germany.
Heidelberg University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In humans, the TRP superfamily of cation channels includes 27 related molecules that respond to a remarkable variety of chemical and physical stimuli. While physiological roles for many TRP channels remain unknown, over the past years several have been shown to function as molecular sensors in organisms ranging from yeast to humans. In particular, TRP channels are now known to constitute important components of sensory systems, where they participate in the detection or transduction of osmotic, mechanical, thermal, or chemosensory stimuli. We here summarize our current understanding of the role individual members of this versatile receptor family play in thermosensation and thermoregulation, and also touch upon their immerging role in metabolic control.

Indexed as

BBB, blood-brain barrierCFO, circumferential organdorsal root ganglionDRG, dorsal root ganglionhypothalamusnociceptionPOA/AH, preoptic area and anterior hypothalamussomatosensationTb, body core temperaturetemperature homeostasisTG, trigeminal ganglionthermoregulationthermosensationTRP ion channelsTRP, transient receptor potential

Identifiers

PMID27227022
PMCPMC4843888
OpenAlexW1890090833

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.