ArticleJundishapur journal of microbiology2016
The High Prevalence of the Varicella Zoster Virus in Patients With Relapsing-Remitting Multiple Sclerosis: A Case-Control Study in the North of Iran.
Article in Jundishapur journal of microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Up-to-date knowledge about the association between multiple sclerosis and the reactivation of human endogenous retrovirus infections.Journal of neurology · 2018Pooled it
- Article
- Immunopathogenesis of viral infections in neurological autoimmune disease.BMC neurology · 2023Review
- T-Cell Response against Varicella Zoster Virus in Patients with Multiple Sclerosis during Relapse and Remission.International journal of molecular sciences · 2021Article
- Environmental risk factors of multiple sclerosis in the Middle East and North Africa region: A systematic review.Current journal of neurology · 2021Review
- Immune-mediated genesis of multiple sclerosis.Journal of translational autoimmunity · 2020Review
- COVID-19 and Multiple Sclerosis: Predisposition and Precautions in Treatment.SN comprehensive clinical medicine · 2020Review
- Varicella infection in the Middle East: Prevalence, complications, and vaccination.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2018Review
- Viruses and endogenous retroviruses in multiple sclerosis: From correlation to causation.Acta neurologica Scandinavica · 2017Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMultiple sclerosis (MS) is the most common neurological autoimmune disease, characterized by multifocal areas of inflammatory demyelination within the central nervous system. It has been hypothesized that the stimulation of the immune system by viral infections is the leading cause of MS among susceptible individuals.
objectivesThe aim of this study was to investigate the prevalence of the varicella zoster virus (VZV) in patients with relapsing-remitting multiple sclerosis. PATIENTS AND
methodsPlasma and peripheral blood mononuclear cells (PBMCs) collected from MS patients (n = 82) and controls (n = 89) were screened for the presence of anti-VZV antibodies and VZV DNA by the ELISA and PCR methods. DNA was extracted from all samples, and VZV infection was examined by the PCR technique. Statistical analysis was used to investigate the frequency of the virus in MS patients and a healthy control group.
resultsOf all the MS patients, 78 (95.1%) and 21 (25.6%) were positive for anti-VZV and VZV DNA, respectively. Statistical analysis of the PCR results showed a significant correlation between the abundance of VZV and MS disease (P < 0.001). However, there was no significant correlation between the abundance of anti-VZV antibodies and MS disease by the ELISA method.
conclusionsThese results support the hypothesis that VZV may contribute to MS in establishing a systemic infection process and inducing an immune response.
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