Evidence map›Paper›PMID 27226737›Full record

ReviewBiomarkers in cancer2016

Targeted Radionuclide Therapy: Practical Applications and Future Prospects.

Katherine Zukotynski, Hossein Jadvar, Jacek Capala, Frederic Fahey

Abstract readReview
In one paragraph

Review in Biomarkers in cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Framework to calculateMedical physics · 2025
    Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Combination of [Pharmaceutics · 2022
    Article
  11. Review
  12. Targeted α-therapy in non-prostate malignancies.European journal of nuclear medicine and molecular imaging · 2021
    Review
  13. Specific Cytotoxicity of TargetedBulletin of experimental biology and medicine · 2021
    Article
  14. Review
  15. Article
  16. Internal microdosimetry of alpha-emitting radionuclides.Radiation and environmental biophysics · 2020
    Review
  17. Current medicinal chemistry · 2020
    Review
  18. Review
  19. Advancing Targeted Radionuclide Therapy Through the National Cancer Institute's Small Business Innovation Research Pathway.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019
    Article
  20. The British journal of radiology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Katherine ZukotynskiDepartments of Radiology and Medicine, McMaster University, Hamilton, ON, Canada.
Hossein JadvarDepartment of Radiology, University of Southern California, Los Angeles, CA, USA.
Jacek CapalaDivision of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Frederic FaheyDepartment of Radiology, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.

Funding

FDG PET-CT in Metastatic Prostate CancerR01CA111613 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JADVAR, HOSSEIN · 2005 to 2010
$2.5M
Pilot Human Studies of FMAU PET in Prostate CancerR21EB017568 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JADVAR, HOSSEIN · 2015 to 2016
$433k
[F18]FMAU in Prostate CancerR21CA142426 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JADVAR, HOSSEIN · 2009 to 2010
$393k
NCI NIH HHS R01 CA111613NCI NIH HHS R21 CA142426NIBIB NIH HHS R21 EB017568
6 · The paper itself

Abstract

In recent years, there has been a proliferation in the development of targeted radionuclide cancer therapy. It is now possible to use baseline clinical and imaging assessments to determine the most effective therapy and to tailor this therapy during the course of treatment based on radiation dosimetry and tumor response. Although this personalized approach to medicine has the advantage of maximizing therapeutic effect while limiting toxicity, it can be challenging to implement and expensive. Further, in order to use targeted radionuclide therapy effectively, there is a need for multidisciplinary awareness, education, and collaboration across the scientific, industrial, and medical communities. Even more important, there is a growing understanding that combining radiopharmaceuticals with conventional treatment such as chemotherapy and external beam radiotherapy may limit patient morbidity while improving survival. Developments in radiopharmaceuticals as biomarkers capable of predicting therapeutic response and targeting disease are playing a central role in medical research. Adoption of a practical approach to manufacturing and delivering radiopharmaceuticals, assessing patient eligibility, optimizing post-therapy follow-up, and addressing reimbursement issues will be essential for their success.

Indexed as

oncologyradionuclide therapytargeted

Identifiers

PMID27226737
PMCPMC4874742

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.