Observational studyInternational journal of chronic obstructive pulmonary disease2016
Quantitative computed tomography measurements of emphysema for diagnosing asthma-chronic obstructive pulmonary disease overlap syndrome.
Observational study in International journal of chronic obstructive pulmonary disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Computed Tomography-Based Evaluation of Airway Remodeling for Distinguishing Asthma-Chronic Obstructive Pulmonary Disease Overlap From Asthma and Chronic Obstructive Pulmonary Disease.Canadian respiratory journal · 2026Article
- Quantitative CT Metrics for the Prediction of Therapeutic Effect in Asthma.Journal of clinical medicine · 2023Article
- Early Diagnosis of High-Risk Chronic Obstructive Pulmonary Disease Based on Quantitative High-Resolution Computed Tomography Measurements.International journal of chronic obstructive pulmonary disease · 2023Article
- Emphysematous changes and lower levels of plasma irisin are associated with bronchiolitis obliterans syndrome after bilateral living-donor lobar lung transplantation.Surgery today · 2022Article
- Novel imaging phenotypes of naïve asthma patients with distinctive clinical characteristics and T2 inflammation traits.Therapeutic advances in chronic disease · 2022Article
- Similarities in Quantitative Computed Tomography Imaging of the Lung in Severe Asthma with Persistent Airflow Limitation and Chronic Obstructive Pulmonary Disease.Journal of clinical medicine · 2021Article
- Asthma and COPD Are Not Risk Factors for ICU Stay and Death in Case of SARS-CoV2 Infection.The journal of allergy and clinical immunology. In practice · 2021Article
- Article
- The features of AECOPD with carbon dioxide retention.BMC pulmonary medicine · 2018Article
- Plasma YKL-40 and NGAL are useful in distinguishing ACO from asthma and COPD.Respiratory research · 2018Article
- Burden of asthma and COPD overlap (ACO) in Taiwan: a nationwide population-based study.BMC pulmonary medicine · 2018Article
- Risk factors predict frequent hospitalization in patients with acute exacerbation of COPD.International journal of chronic obstructive pulmonary disease · 2018Article
- High prevalence of bronchiectasis in emphysema-predominant COPD patients.International journal of chronic obstructive pulmonary disease · 2018Article
- Sagittal-lung CT measurements in the evaluation of asthma-COPD overlap syndrome: a distinctive phenotype from COPD alone.La Radiologia medica · 2017Article
- Role of inspiratory capacity on dyspnea evaluation in COPD with or without emphysematous lesions: a pilot study.International journal of chronic obstructive pulmonary disease · 2017Article
- Decreased levels of irisin, a skeletal muscle cell-derived myokine, are related to emphysema associated with chronic obstructive pulmonary disease.International journal of chronic obstructive pulmonary disease · 2017Article
- Current situation of asthma-COPD overlap syndrome (ACOS) in Chinese patients older than 40 years with airflow limitation: rationale and design for a multicenter, cross-sectional trial (study protocol).Journal of thoracic disease · 2016Article
- A morphologic study of the airway structure abnormalities in patients with asthma by high-resolution computed tomography.Journal of thoracic disease · 2016Article
- Quantitative computed tomography: what does airway obstruction look-like?Journal of thoracic disease · 2016Article
- Computer quantification of "angle of collapse" on maximum expiratory flow volume curve for diagnosing asthma-COPD overlap syndrome.International journal of chronic obstructive pulmonary disease · 2016Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe diagnostic criteria of asthma-COPD overlap syndrome (ACOS) are controversial. Emphysema is characteristic of COPD and usually does not exist in typical asthma patients. Emphysema in patients with asthma suggests the coexistence of COPD. Quantitative computed tomography (CT) allows repeated evaluation of emphysema noninvasively. We investigated the value of quantitative CT measurements of emphysema in the diagnosis of ACOS.
methodsThis study included 404 participants; 151 asthma patients, 125 COPD patients, and 128 normal control subjects. All the participants underwent pulmonary function tests and a high-resolution CT scan. Emphysema measurements were taken with an Airway Inspector software. The asthma patients were divided into high and low emphysema index (EI) groups based on the percentage of low attenuation areas less than -950 Hounsfield units. The characteristics of asthma patients with high EI were compared with those having low EI or COPD.
resultsThe normal value of percentage of low attenuation areas less than -950 Hounsfield units in Chinese aged >40 years was 2.79%±2.37%. COPD patients indicated more severe emphysema and more upper-zone-predominant distribution of emphysema than asthma patients or controls. Thirty-two (21.2%) of the 151 asthma patients had high EI. Compared with asthma patients with low EI, those with high EI were significantly older, more likely to be male, had more pack-years of smoking, had more upper-zone-predominant distribution of emphysema, and had greater airflow limitation. There were no significant differences in sex ratios, pack-years of smoking, airflow limitation, or emphysema distribution between asthma patients with high EI and COPD patients. A greater number of acute exacerbations were seen in asthma patients with high EI compared with those with low EI or COPD.
conclusionAsthma patients with high EI fulfill the features of ACOS, as described in the Global Initiative for Asthma and Global Initiative for Chronic Obstructive Lung Disease guidelines. Quantitative CT measurements of emphysema may help in diagnosing ACOS.
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