ArticleThe Journal of biological chemistry2016
Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity.
Article in The Journal of biological chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 67 citations in OpenAlex.
- Cashew-Derived Flavonoids Modulate the Th1/Th2 Balance at Peyer's Patches via a C-Ring Oxidation-Dependent Molecular Switch.Journal of food science · 2026Article
- Synthesis of Isochromans From Anacardic Acids Obtained From Cashew Nutshell Liquid (CNSL) and Their Antimicrobial Activity.Chemistry & biodiversity · 2026Article
- Systematic Characterization of Antioxidant Shielding Capacity Against Oxidative Stress of Aerial Part Extracts ofAntioxidants (Basel, Switzerland) · 2025Article
- Structural Analysis of Cardanol and Its Biological Activities on Human Keratinocyte Cells.Metabolites · 2025Article
- From Nature to Drug: Overview and CADD Approach of Anacardic Acid to Propose their Biological Potential.Current topics in medicinal chemistry · 2025Review
- Review
- Validation of a Method for Anacardic Acid Quantification in Cashew Peduncles via High-Performance Liquid Chromatography Coupled to a Diode-Array Detector.Foods (Basel, Switzerland) · 2023Article
- Diet-gut microbial interactions influence cancer immunotherapy.Frontiers in oncology · 2023Review
- Gut microbiota influence immunotherapy responses: mechanisms and therapeutic strategies.Journal of hematology & oncology · 2022Review
- Intestinal microbiota and its interaction to intestinal health in nursery pigs.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Review
- Supplemental Effects of Functional Oils on the Modulation of Mucosa-Associated Microbiota, Intestinal Health, and Growth Performance of Nursery Pigs.Animals : an open access journal from MDPI · 2021Article
- Review
- New Insights Into the Cancer-Microbiome-Immune Axis: Decrypting a Decade of Discoveries.Frontiers in immunology · 2021Review
- Phagocytosis, Degranulation and Extracellular Traps Release by Neutrophils-The Current Knowledge, Pharmacological Modulation and Future Prospects.Frontiers in pharmacology · 2021Review
- Effect of Castor and Cashew Nut Shell Oils, Selenium and Vitamin E as Antioxidants on the Health and Meat Stability of Lambs Fed a High-Concentrate Diet.Antioxidants (Basel, Switzerland) · 2020Article
- Neutrophils as a Novel Target of Modified Low-Density Lipoproteins and an Accelerator of Cardiovascular Diseases.International journal of molecular sciences · 2020Review
- Catechin isolated from cashew nut shell exhibits antibacterial activity against clinical isolates of MRSA through ROS-mediated oxidative stress.Applied microbiology and biotechnology · 2020Article
- Current Concepts in Pharmacometabolomics, Biomarker Discovery, and Precision Medicine.Metabolites · 2020Review
- Combinatorial Epigenetics Impact of Polyphenols and Phytochemicals in Cancer Prevention and Therapy.International journal of molecular sciences · 2019Review
- Post-Translational Modifications in NETosis and NETs-Mediated Diseases.Biomolecules · 2019Review
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
Abstract
Emerging antibiotic resistance among pathogenic bacteria is an issue of great clinical importance, and new approaches to therapy are urgently needed. Anacardic acid, the primary active component of cashew nut shell extract, is a natural product used in the treatment of a variety of medical conditions, including infectious abscesses. Here, we investigate the effects of this natural product on the function of human neutrophils. We find that anacardic acid stimulates the production of reactive oxygen species and neutrophil extracellular traps, two mechanisms utilized by neutrophils to kill invading bacteria. Molecular modeling and pharmacological inhibitor studies suggest anacardic acid stimulation of neutrophils occurs in a PI3K-dependent manner through activation of surface-expressed G protein-coupled sphingosine-1-phosphate receptors. Neutrophil extracellular traps produced in response to anacardic acid are bactericidal and complement select direct antimicrobial activities of the compound.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.