ArticleJournal of neurophysiology2016
Synaptic integration of transplanted interneuron progenitor cells into native cortical networks.
Article in Journal of neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Both GEF domains of the autism and developmental epileptic encephalopathy-associated Trio protein are required for proper tangential migration of GABAergic interneurons.Molecular psychiatry · 2025Article
- Medial ganglionic eminence transplantation restores inhibition after central visual system brain injury.PNAS nexus · 2025Article
- Host brain environmental influences on transplanted medial ganglionic eminence progenitors.Scientific reports · 2024Article
- Cell therapy for neurological disorders: Progress towards an embryonic medial ganglionic eminence progenitor-based treatment.Frontiers in neuroscience · 2023Review
- Cellular signaling impacts upon GABAergic cortical interneuron development.Frontiers in neuroscience · 2023Review
- Brain-wide reconstruction of inhibitory circuits after traumatic brain injury.Nature communications · 2022Article
- Origin, Development, and Synaptogenesis of Cortical Interneurons.Frontiers in neuroscience · 2022Review
- Effects of synaptic integration on the dynamics and computational performance of spiking neural network.Cognitive neurodynamics · 2020Article
- Interneuron Transplantation Rescues Social Behavior Deficits without Restoring Wild-Type Physiology in a Mouse Model of Autism with Excessive Synaptic Inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Interneuron deficits in neurodevelopmental disorders: Implications for disease pathology and interneuron-based therapies.European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society · 2020Review
- Transplanted interneurons improve memory precision after traumatic brain injury.Nature communications · 2019Article
- Heterotopic Transplantations Reveal Environmental Influences on Interneuron Diversity and Maturation.Cell reports · 2017Article
- Persistent seizure control in epileptic mice transplanted with gamma-aminobutyric acid progenitors.Annals of neurology · 2017Article
- Development and long-term integration of MGE-lineage cortical interneurons in the heterochronic environment.Journal of neurophysiology · 2017Article
- Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling.Journal of visualized experiments : JoVE · 2017Article
- Neuronal replacement therapy: previous achievements and challenges ahead.NPJ Regenerative medicine · 2017Review
- Transplantation of GABAergic interneurons for cell-based therapy.Progress in brain research · 2017Article
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2 authors.
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Abstract
Interneuron-based cell transplantation is a powerful method to modify network function in a variety of neurological disorders, including epilepsy. Whether new interneurons integrate into native neural networks in a subtype-specific manner is not well understood, and the therapeutic mechanisms underlying interneuron-based cell therapy, including the role of synaptic inhibition, are debated. In this study, we tested subtype-specific integration of transplanted interneurons using acute cortical brain slices and visualized patch-clamp recordings to measure excitatory synaptic inputs, intrinsic properties, and inhibitory synaptic outputs. Fluorescently labeled progenitor cells from the embryonic medial ganglionic eminence (MGE) were used for transplantation. At 5 wk after transplantation, MGE-derived parvalbumin-positive (PV+) interneurons received excitatory synaptic inputs, exhibited mature interneuron firing properties, and made functional synaptic inhibitory connections to native pyramidal cells that were comparable to those of native PV+ interneurons. These findings demonstrate that MGE-derived PV+ interneurons functionally integrate into subtype-appropriate physiological niches within host networks following transplantation.
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