ArticleJournal of neurophysiology2016
A combined TMS-EEG study of short-latency afferent inhibition in the motor and dorsolateral prefrontal cortex.
Article in Journal of neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Methodological Choices Matter: A Systematic Comparison of TMS-EEG Studies Targeting the Primary Motor Cortex.Human brain mapping · 2024Pooled it
- The Impact of Sex Hormones on Transcranial Magnetic Stimulation Measures of Cortical Excitability: A Systematic Review and Considerations for Clinical Practice.Harvard review of psychiatryPooled it
- Timing-dependent inhibitory effects of peripheral somatosensory inputs on the primary motor cortex: A transcranial magnetic stimulation-electroencephalography study.Neuroimage. Reports · 2026Article
- Short-Latency Afferent Inhibition and Cognitive Function in Older Adults With Mild Cognitive Impairment: A Pilot Study.Brain & NeuroRehabilitation · 2026Article
- Assessing Neuromodulation Effects of Theta Burst Stimulation to the Prefrontal Cortex Using Transcranial Magnetic Stimulation Electroencephalography (TMS-EEG).The European journal of neuroscience · 2025Article
- Neuroplasticity of the left dorsolateral prefrontal cortex in patients with treatment-resistant depression as indexed with paired associative stimulation: a TMS-EEG study.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- The effects of verbal and spatial working memory on short- and long-latency sensorimotor circuits in the motor cortex.PloS one · 2024Article
- Natural Oscillatory Frequency Slowing in the Premotor Cortex of Early-Course Schizophrenia Patients: A TMS-EEG Study.Brain sciences · 2023Article
- TMS-EEG Research to Elucidate the Pathophysiological Neural Bases in Patients with Schizophrenia: A Systematic Review.Journal of personalized medicine · 2021Review
- Examining and Modulating Neural Circuits in Psychiatric Disorders With Transcranial Magnetic Stimulation and Electroencephalography: Present Practices and Future Developments.The American journal of psychiatry · 2021Review
- Potential Neurophysiological Mechanisms of 1Hz-TMS to the Right Prefrontal Cortex for Depression: An Exploratory TMS-EEG Study in Healthy Participants.Journal of personalized medicine · 2021Article
- Single-Pulse TMS to the Temporo-Occipital and Dorsolateral Prefrontal Cortex Evokes Lateralized Long Latency EEG Responses at the Stimulation Site.Frontiers in neuroscience · 2021Article
- Re-emergent Tremor in Parkinson's Disease: The Role of the Motor Cortex.Movement disorders : official journal of the Movement Disorder Society · 2020Article
- Maturation changes the excitability and effective connectivity of the frontal lobe: A developmental TMS-EEG study.Human brain mapping · 2019Article
- The effects of individualised intermittent theta burst stimulation in the prefrontal cortex: A TMS-EEG study.Human brain mapping · 2019Article
- Impact of different intensities of intermittent theta burst stimulation on the cortical properties during TMS-EEG and working memory performance.Human brain mapping · 2018Article
- Characterization of Glutamatergic and GABANeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Reduced Prefrontal Short-Latency Afferent Inhibition in Older Adults and Its Relation to Executive Function: A TMS-EEG Study.Frontiers in aging neuroscience · 2017Article
- Characterizing and Modulating Brain Circuitry through Transcranial Magnetic Stimulation Combined with Electroencephalography.Frontiers in neural circuits · 2016Review
- TMS evoked N100 reflects local GABA and glutamate balance.Brain stimulationArticle
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Combined transcranial magnetic stimulation and electroencephalography (TMS-EEG) enables noninvasive neurophysiological investigation of the human cortex. A TMS paradigm of short-latency afferent inhibition (SAI) is characterized by attenuation of the motor-evoked potential (MEP) and modulation of N100 of the TMS-evoked potential (TEP) when TMS is delivered to motor cortex (M1) following median nerve stimulation. SAI is a marker of cholinergic activity in the motor cortex; however, the SAI has not been tested from the prefrontal cortex. We aimed to explore the effect of SAI in dorsolateral prefrontal cortex (DLPFC). SAI was examined in 12 healthy subjects with median nerve stimulation and TMS delivered to M1 and DLPFC at interstimulus intervals (ISIs) relative to the individual N20 latency. SAI in M1 was tested at the optimal ISI of N20 + 2 ms. SAI in DLPFC was investigated at a range of ISI from N20 + 2 to N20 + 20 ms to explore its temporal profile. For SAI in M1, the attenuation of MEP amplitude was correlated with an increase of TEP N100 from the left central area. A similar spatiotemporal neural signature of SAI in DLPFC was observed with a marked increase of N100 amplitude. SAI in DLPFC was maximal at ISI N20 + 4 ms at the left frontal area. These findings establish the neural signature of SAI in DLPFC. Future studies could explore whether DLPFC-SAI is neurophysiological marker of cholinergic dysfunction in cognitive disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.