ReviewJournal of neurophysiology2016
Respiratory and autonomic dysfunction in congenital central hypoventilation syndrome.
Review in Journal of neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Transitional care and clinical management of adolescents, young adults, and suspected new adult patients with congenital central hypoventilation syndrome.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Pooled it
- Sympathetic Chain Ganglia in the Female Pig During Prenatal Development: Noradrenergic and Cholinergic Neurons.Current issues in molecular biology · 2026Article
- Article
- Genetic identification of medullary neurons underlying congenital hypoventilation.Science advances · 2024Article
- Organoid models of breathing disorders reveal patterning defect of hindbrain neurons caused by PHOX2B-PARMs.Stem cell reports · 2023Article
- Article
- Effects of Cervical Spine Mobilization on Respiratory Function and Cervical Angles of Stroke Patients: A Pilot Study.Healthcare (Basel, Switzerland) · 2021Article
- Respiratory Control by Phox2b-expressing Neurons in a Locus Coeruleus-preBötzinger Complex Circuit.Neuroscience bulletin · 2021Article
- Editorial: Updates on the Neuropathology of Sudden Unexplained Perinatal Death and Other Neurodevelopmental Disorders.Frontiers in neurology · 2021Article
- Machine learning-based data analytic approaches for evaluating post-natal mouse respiratory physiological evolution.Respiratory physiology & neurobiology · 2021Article
- Recognizing genetic disease: A key aspect of pediatric pulmonary care.Pediatric pulmonology · 2020Review
- Research Advances on Therapeutic Approaches to Congenital Central Hypoventilation Syndrome (CCHS).Frontiers in neuroscience · 2020Review
- Insights into the dynamic control of breathing revealed through cell-type-specific responses to substance P.eLife · 2019Article
- Individual long non-coding RNAs have no overt functions in zebrafish embryogenesis, viability and fertility.eLife · 2019Article
- Differential Role of Pontomedullary Glutamatergic Neuronal Populations in Sleep-Wake Control.Frontiers in neuroscience · 2019Article
- The genetics of congenital central hypoventilation syndrome: clinical implications.The application of clinical genetics · 2018Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The developmental lineage of the PHOX2B-expressing neurons in the retrotrapezoid nucleus (RTN) has been extensively studied. These cells are thought to function as central respiratory chemoreceptors, i.e., the mechanism by which brain Pco2 regulates breathing. The molecular and cellular basis of central respiratory chemoreception is based on the detection of CO2 via intrinsic proton receptors (TASK-2, GPR4) as well as synaptic input from peripheral chemoreceptors and other brain regions. Murine models of congenital central hypoventilation syndrome designed with PHOX2B mutations have suggested RTN neuron agenesis. In this review, we examine, through human and experimental animal models, how a restricted number of neurons that express the transcription factor PHOX2B play a crucial role in the control of breathing and autonomic regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.