ArticleCerebral cortex (New York, N.Y. : 1991)2017
Reconfiguration of Intrinsic Functional Coupling Patterns Following Circumscribed Network Lesions.
Article in Cerebral cortex (New York, N.Y. : 1991), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Relationships between local metabolic activity and distributed functional connectivity in major depressive disorder.Translational psychiatry · 2025Article
- Using mechanistic knowledge to appraise contemporary approaches to the rehabilitation of upper limb function following stroke.The Journal of physiology · 2025Review
- Characterization of structural and functional network organization after focal prefrontal lesions in humans in proof of principle study.Brain structure & function · 2022Article
- Mapping correlated neurological deficits after stroke to distributed brain networks.Brain structure & function · 2022Review
- Longitudinal assessment of network reorganizations and language recovery in postoperative patients with glioma.Brain communications · 2022Article
- The role of the medial prefrontal cortex in cognition, ageing and dementia.Brain communications · 2021Review
- Should Complex Cognitive Functions Be Mapped With Direct Electrostimulation in Wide-Awake Surgery? A Network Perspective.Frontiers in neurology · 2021Article
- Damage to the shortest structural paths between brain regions is associated with disruptions of resting-state functional connectivity after stroke.NeuroImage · 2020Article
- Regions and Connections: Complementary Approaches to Characterize Brain Organization and Function.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2020Review
- Structural Disconnections Explain Brain Network Dysfunction after Stroke.Cell reports · 2019Article
- Functional Connectivity-Based Modelling Simulates Subject-Specific Network Spreading Effects of Focal Brain Stimulation.Neuroscience bulletin · 2018Article
- Neuropsychology and cognitive neuroscience in the fMRI era: A recapitulation of localizationist and connectionist views.Neuropsychology · 2017Article
- Linking left hemispheric tissue preservation to fMRI language task activation in chronic stroke patients.Cortex; a journal devoted to the study of the nervous system and behavior · 2017Article
- Hypoconnectivity of Resting-State Networks in Persons with Aphasia Compared with Healthy Age-Matched Adults.Frontiers in human neuroscience · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Communication between cortical regions is necessary for optimal cognitive processing. Functional relationships between cortical regions can be inferred through measurements of temporal synchrony in spontaneous activity patterns. These relationships can be further elaborated by surveying effects of cortical lesions upon inter-regional connectivity. Lesions to cortical hubs and heteromodal association regions are expected to induce distributed connectivity changes and higher-order cognitive deficits, yet their functional consequences remain relatively unexplored. Here, we used resting-state fMRI to investigate intrinsic functional connectivity (FC) and graph theoretical metrics in 12 patients with circumscribed lesions of the medial prefrontal cortex (mPFC) portion of the Default Network (DN), and compared these metrics with those observed in healthy matched comparison participants and a sample of 1139 healthy individuals. Despite significant mPFC destruction, patients did not demonstrate weakened intrinsic FC among undamaged DN nodes. Instead, network-specific changes were manifested as weaker negative correlations between the DN and attentional and somatomotor networks. These findings conflict with the DN being a homogenous system functionally anchored at mPFC. Rather, they implicate a role for mPFC in mediating cross-network functional interactions. More broadly, our data suggest that lesions to association cortical hubs might induce clinical deficits by disrupting communication between interacting large-scale systems.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.