ArticleDrug and alcohol dependence2016
Objective and specific tracking of anhedonia via event-related potentials in individuals with cocaine use disorders.
Article in Drug and alcohol dependence, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- Repurposing semaglutide as an adjunctive treatment for cocaine use disorder: protocol for a randomised controlled trial.BMJ open · 2026Article
- Inefficient integration between effort and reward in anhedonia.Psychological medicine · 2026Article
- Positive valence system function and anhedonia in middle-aged and older adults at high suicide risk.Biological psychology · 2023Article
- Assessing cocaine motivational value: Comparison of brain reactivity bias toward cocaine cues and cocaine demand.Experimental and clinical psychopharmacology · 2023Article
- Δ9-THC reduces reward-related brain activity in healthy adults.Psychopharmacology · 2022Article
- Addressing racial and phenotypic bias in human neuroscience methods.Nature neuroscience · 2022Review
- Win, lose, or draw: Examining salience, reward memory, and depression with the reward positivity.Psychophysiology · 2022Article
- Addiction, Anhedonia, and Comorbid Mood Disorder. A Narrative Review.Frontiers in psychiatry · 2019Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundHyposensitivity to non-drug reward, behaviorally manifested as anhedonia, is a hallmark of chronic substance use. Anhedonia is a transdiagnostic symptom underpinned by neurobiochemical disturbances in the reward circuit, yet an objective measure to assess anhedonia severity still eludes the field. We hypothesized that the Reward Positivity (RewP) component of the event-related potentials (ERPs) will specifically track anhedonia as the RewP is attributed to the same brain regions that are also implicated in anhedonia.
methodsForty-six individuals with cocaine use disorders (iCUD) performed a gambling task predicting whether they would win or lose money on each trial, while ERP data was acquired. RewP in response to predicted win trials was extracted from the ERPs using the principal component analysis. State anhedonia and depression severity were assessed using the Cocaine Selective Severity Assessment (CSSA).
resultsAlthough RewP amplitude correlated with both anhedonia and depression, only the RewP-anhedonia correlation survived a correction for depression severity. Further, a hierarchical multiple regression analysis revealed that anhedonia explained a significant amount of variance in the RewP amplitude, and this variance was significantly greater than that explained by demographics, severity and recency of drug use and even depression.
conclusionsThese results show that RewP amplitude in response to rewarded trials tracks state anhedonia severity in iCUD. We argue that this association is perhaps driven by the activity in the dopaminergic mesocorticolimbic reward pathway that may underlie anhedonia symptomology as well as modulate RewP amplitude.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.