ArticleProceedings of the National Academy of Sciences of the United States of America2016
New paradigm to assess brain cell morphology by diffusion-weighted MR spectroscopy in vivo.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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45 citing papers in PubMed, 105 citations in OpenAlex.
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- Scattering approach to diffusion quantifies axonal damage in brain injury.Nature communications · 2025Article
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- Diffusion of brain metabolites highlights altered brain microstructure in type C hepatic encephalopathy: a 9.4 T preliminary study.Frontiers in neuroscience · 2024Article
- Investigating exchange, structural disorder, and restriction in gray matter via water and metabolites diffusivity and kurtosis time-dependence.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Fast multi-compartment Microstructure Fingerprinting in brain white matter.Frontiers in neuroscience · 2024Article
- Molecular Imaging with Aquaporin-Based Reporter Genes: Quantitative Considerations from Monte Carlo Diffusion Simulations.ACS synthetic biology · 2023Article
- Molecular imaging with aquaporin-based reporter genes: quantitative considerations from Monte Carlo diffusion simulations.bioRxiv : the preprint server for biology · 2023Article
- The future is 2D: spectral-temporal fitting of dynamic MRS data provides exponential gains in precision over conventional approaches.Magnetic resonance in medicine · 2023Article
- Macromolecular background signal and non-Gaussian metabolite diffusion determined in human brain using ultra-high diffusion weighting.Magnetic resonance in medicine · 2022Article
- Diffusion MRI signal cumulants and hepatocyte microstructure at fixed diffusion time: Insights from simulations, 9.4T imaging, and histology.Magnetic resonance in medicine · 2022Article
- Using Advanced Diffusion-Weighted Imaging to Predict Cell Counts in Gray Matter: Potential and Pitfalls.Frontiers in neuroscience · 2022Article
- Mapping complex cell morphology in the grey matter with double diffusion encoding MR: A simulation study.NeuroImage · 2021Article
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10 authors at 5 institutions in 1 country.
Funding
Abstract
The brain is one of the most complex organs, and tools are lacking to assess its cellular morphology in vivo. Here we combine original diffusion-weighted magnetic resonance (MR) spectroscopy acquisition and novel modeling strategies to explore the possibility of quantifying brain cell morphology noninvasively. First, the diffusion of cell-specific metabolites is measured at ultra-long diffusion times in the rodent and primate brain in vivo to observe how cell long-range morphology constrains metabolite diffusion. Massive simulations of particles diffusing in synthetic cells parameterized by morphometric statistics are then iterated to fit experimental data. This method yields synthetic cells (tentatively neurons and astrocytes) that exhibit striking qualitative and quantitative similarities with histology (e.g., using Sholl analysis). With our approach, we measure major interspecies difference regarding astrocytes, whereas dendritic organization appears better conserved throughout species. This work suggests that the time dependence of metabolite diffusion coefficient allows distinguishing and quantitatively characterizing brain cell morphologies noninvasively.
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