ArticleProteomics2016
MALDI-MSI for the analysis of a 3D tissue-engineered psoriatic skin model.
Article in Proteomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Recent advances in immunocompetent human skin-on-chip models: Construction strategies and biomedical applications.Bioactive materials · 2026Review
- Visualization of oxygen profile in reconstructed human epidermis by phosphorescence-lifetime imaging microscopy using Ir(III) complex.Scientific reports · 2025Article
- Ferroptosis of select skin epithelial cells initiates and maintains chronic systemic immune-mediated psoriatic disease.The Journal of clinical investigation · 2024Article
- SkinCom, a synthetic skin microbial community, enables reproducible investigations of the human skin microbiome.Cell reports methods · 2024Article
- Development of a Mass Spectrometry Imaging Method to Evaluate the Penetration of Moisturizing Components Coated on Surgical Gloves into Artificial Membranes.Mass spectrometry (Tokyo, Japan) · 2024Article
- Review
- A Comprehensive Comparison of Tissue Processing Methods for High-Quality MALDI Imaging of Lipids in Reconstructed Human Epidermis.Journal of the American Society for Mass Spectrometry · 2023Article
- An innervated skin 3D in vitro model for dermatological research.In vitro models · 2023Article
- -Omics potential of in vitro skin models for radiation exposure.Cellular and molecular life sciences : CMLS · 2022Review
- In Vitro Models Mimicking Immune Response in the Skin.Yonsei medical journal · 2021Review
- The application of label-free imaging technologies in transdermal research for deeper mechanism revealing.Asian journal of pharmaceutical sciences · 2021Review
- Direct identification of bacterial and human proteins from infected wounds in living 3D skin models.Scientific reports · 2020Article
- Characterizing the Natural History of Acute Radiation Syndrome of the Gastrointestinal Tract: Combining High Mass and Spatial Resolution Using MALDI-FTICR-MSI.Health physics · 2019Article
- Proteomics in Psoriasis.International journal of molecular sciences · 2019Review
- Immortalized N/TERT keratinocytes as an alternative cell source in 3D human epidermal models.Scientific reports · 2017Article
- In vitro psoriasis models with focus on reconstructed skin models as promising tools in psoriasis research.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- Role of MALDI-MSI in combination with 3D tissue models for early stage efficacy and safety testing of drugs and toxicants.Expert review of proteomicsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
MALDI-MS Imaging is a novel label-free technique that can be used to visualize the changes in multiple mass responses following treatment. Following treatment with proinflammatory cytokine interleukin-22 (IL-22), the epidermal differentiation of Labskin, a living skin equivalent (LSE), successfully modeled psoriasis in vitro. Masson's trichrome staining enabled visualization and quantification of epidermal differentiation between the untreated and IL-22 treated psoriatic LSEs. Matrix-assisted laser desorption ionization mass spectrometry imaging was used to observe the spatial location of the psoriatic therapy drug acetretin following 48 h treatments within both psoriatic and normal LSEs. After 24 h, the drug was primarily located in the epidermal regions of both the psoriatic and nonpsoriatic LSE models whereas after 48 h it was detectible in the dermis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.