Evidence map›Paper›PMID 27226209›Full record

SynthesisAnnals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc2016

Application of Heart Rate Variability in Diagnosis and Prognosis of Individuals with Diabetes Mellitus: Systematic Review.

Anne Kastelianne França da Silva, Marianne Penachini da Costa de Rezende Barbosa, Franciele Marques Vanderlei, Diego Giuliano Destro Christofaro, Luiz Carlos Marques Vanderlei

Abstract readSystematic Review
In one paragraph

Synthesis in Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Observational
  5. Heart rate variability in unstably housed Veterans with mental health conditions.Journal of clinical and experimental neuropsychology · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Heart rate variability in anaesthesiology - narrative review.Anaesthesiology intensive therapy · 2023
    Review
  10. Entropy of Heart Rate on Self-Selected Interval Exercises in Older Women.International journal of exercise science · 2023
    Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Impact of functional training on geometric indices and fractal correlation property of heart rate variability in postmenopausal women.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2018
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anne Kastelianne França da SilvaPhysical Therapy, Faculty of Science and Technology, Paulista State University, Presidente Prudente, São Paulo, Brazil.
Marianne Penachini da Costa de Rezende BarbosaHealth Sciences, Faculty of Medicine in ABC, Santo André, São Paulo, Brazil.
Franciele Marques VanderleiDepartment of Physical Therapy, Faculty of Science and Technology, Paulista State University, Presidente Prudente, São Paulo, Brazil.
Diego Giuliano Destro ChristofaroDepartment of Physical Education, Faculty of Science and Technology, Paulista State University, Presidente Prudente, São Paulo, Brazil.
Luiz Carlos Marques VanderleiDepartment of Physical Therapy, Faculty of Science and Technology, Paulista State University, Presidente Prudente, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe use of heart rate variability as a tool capable of discriminating individuals with diabetes mellitus is still little explored, as its use has been limited to comparing those with and without the disease. Thus, the purpose of this study was to verify the use of heart rate variability as a tool for diagnostic and prognostic evaluation in person with diabetes and to identify whether there are cutoff points generated from the use of this tool in these individuals.

methodsA search was conducted in the electronic databases MEDLINE, Cochrane Library, Web of Science, EMBASE, and LILACS starting from the oldest records until January 2015, by means of descriptors related to the target condition, evaluated tool, and evaluation method. All the studies were evaluated for methodological quality using the QUADAS-2 instrument.

resultsEight studies were selected. In general, the studies showed that the heart rate variability is useful to discriminate cardiac autonomic neuropathy in person with diabetes, and the sample entropy, SD1/SD2 indices, SDANN, HF, and slope of TFC have better discriminatory power to detect autonomic dysfunction, with sensitivity and specificity values ranging from 72% to 100% and 71% to 97%, respectively.

conclusionAlthough there are methodological differences in indices used, in general, this tool demonstrated good sensitivity and specificity and can be used as an additional and/or complementary tool to the conventional autonomic tests, in order to obtain safer and more effective diagnostic, collaborating for better risk stratification conditions of these patients.

Indexed as

Heart Rate DeterminationAutonomic Nervous SystemDiabetes MellitusHumansPrognosisSensitivity and Specificityautonomic nervous systemdiabetes mellituselectrocardiographyheart ratesensitivity and specificity

Identifiers

PMID27226209
PMCPMC6931580

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.