ArticleNature communications2016
Dynamic heterogeneity and non-Gaussian statistics for acetylcholine receptors on live cell membrane.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Dynamic heterogeneity and hidden fluidity in dense epithelial tissues.Science advances · 2026Article
- Single-particle tracking reveals heterogeneous PIEZO1 diffusion.Biophysical journal · 2025Article
- Protein drift-diffusion in membranes with non-equilibrium fluctuations arising from gradients in concentration or temperature.PLoS computational biology · 2025Article
- Chemiosmotic ATP synthesis by minimal protocells.Cell reports. Physical science · 2025Article
- Phage probes couple to DNA relaxation dynamics to reveal universal behavior across scales and regimes.Soft matter · 2025Article
- Protein translation can fluidize bacterial cytoplasm.PNAS nexus · 2024Article
- Diffusion in Porous Rock Is Anomalous.Environmental science & technology · 2024Article
- Statistical laws of stick-slip friction at mesoscale.Nature communications · 2023Article
- Simulation Study on the Mechanism of Intermediate Subdiffusion of Diffusive Particles in Crowded Systems.ACS omega · 2023Article
- Heterogeneous biological membranes regulate protein partitioning via fluctuating diffusivity.PNAS nexus · 2023Article
- Lipid packing in biological membranes governs protein localization and membrane permeability.Biophysical journal · 2023Article
- Fickian yet non-Gaussian diffusion of a quasi-2D colloidal system in an optical speckle field: experiment and simulations.Scientific reports · 2023Article
- Universal Evolution of Fickian Non-Gaussian Diffusion in Two- and Three-Dimensional Glass-Forming Liquids.International journal of molecular sciences · 2023Article
- Heterogeneity of cell membrane structure studied by single molecule tracking.Faraday discussions · 2021Article
- Intracellular transport dynamics revealed by single-particle tracking.Biophysics reports · 2021Article
- Local Analysis of Heterogeneous Intracellular Transport: Slow and Fast Moving Endosomes.Entropy (Basel, Switzerland) · 2021Article
- OCRL regulates lysosome positioning and mTORC1 activity through SSX2IP-mediated microtubule anchoring.EMBO reports · 2021Article
- Glass-like characteristics of intracellular motion in human cells.Biophysical journal · 2021Article
- Fluctuating Diffusivity of RNA-Protein Particles: Analogy with Thermodynamics.Entropy (Basel, Switzerland) · 2021Article
- From diffusion in compartmentalized media to non-Gaussian random walks.Scientific reports · 2021Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Brownian motion of molecules at thermal equilibrium usually has a finite correlation time and will eventually be randomized after a long delay time, so that their displacement follows the Gaussian statistics. This is true even when the molecules have experienced a complex environment with a finite correlation time. Here, we report that the lateral motion of the acetylcholine receptors on live muscle cell membranes does not follow the Gaussian statistics for normal Brownian diffusion. From a careful analysis of a large volume of the protein trajectories obtained over a wide range of sampling rates and long durations, we find that the normalized histogram of the protein displacements shows an exponential tail, which is robust and universal for cells under different conditions. The experiment indicates that the observed non-Gaussian statistics and dynamic heterogeneity are inherently linked to the slow-active remodelling of the underlying cortical actin network.
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