ArticleScientific reports2016
Alpha-ketoglutarate promotes skeletal muscle hypertrophy and protein synthesis through Akt/mTOR signaling pathways.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 55 citations in OpenAlex.
- Impact of infant protein supply and other early life factors on plasma metabolome at 5.5 and 8 years of age: a randomized trial.International journal of obesity (2005) · 2020Trial
- Kaempferol Improves Exercise Performance by Regulating Glucose Uptake, Mitochondrial Biogenesis, and Protein Synthesis via PI3K/AKT and MAPK Signaling Pathways.Foods (Basel, Switzerland) · 2024Article
- Identification of Active Components for Sports Supplements: Machine Learning-Driven Classification and Cell-Based Validation.ACS omega · 2024Article
- Review
- NMR-Based Metabolic Profiling of the Effects of α-Ketoglutarate Supplementation on Energy-Deficient C2C12 Myotubes.Molecules (Basel, Switzerland) · 2023Article
- Metabolic regulation by biomaterials in osteoblast.Frontiers in bioengineering and biotechnology · 2023Review
- Nanohydroxyapatite-Blasted Bioactive Surface Drives Shear-Stressed Endothelial Cell Growth and Angiogenesis.BioMed research international · 2022Article
- In-vitro and in-vivo functional observation studies to establish therapeutic potential of alpha-ketoglutarate against methotrexate induced liver injury.Biomedical journal · 2021Article
- Nuclear factor E2-related factor 2 (NRF2) deficiency accelerates fast fibre type transition in soleus muscle during space flight.Communications biology · 2021Article
- NMR-Based Metabolomic Analysis for the Effects of α-Ketoglutarate Supplementation on C2C12 Myoblasts in Different Energy States.Molecules (Basel, Switzerland) · 2021Article
- Mechanisms of muscle atrophy and hypertrophy: implications in health and disease.Nature communications · 2021Review
- Molecular mechanisms of cancer cachexia‑induced muscle atrophy (Review).Molecular medicine reports · 2020Review
- Indoprofen prevents muscle wasting in aged mice through activation of PDK1/AKT pathway.Journal of cachexia, sarcopenia and muscle · 2020Article
- Metabolic Regulation of Human Pluripotent Stem Cell-Derived Cardiomyocyte Maturation.Current cardiology reports · 2020Review
- Exercise-induced α-ketoglutaric acid stimulates muscle hypertrophy and fat loss through OXGR1-dependent adrenal activation.The EMBO journal · 2020Observational
- Potential Roles of Exercise-Induced Plasma Metabolites Linking Exercise to Health Benefits.Frontiers in physiology · 2020Review
- Comparative Transcriptome Profile Analysis ofFrontiers in genetics · 2020Article
- Supplements with purported effects on muscle mass and strength.European journal of nutrition · 2019Review
- Succinate induces skeletal muscle fiber remodeling via SUNCR1 signaling.EMBO reports · 2019Article
- Oral supplementation with ginseng polysaccharide promotes food intake in mice.Brain and behavior · 2019Article
Corrections and comments
- Retraction · 2020-10-28Concerns/Issues about Data · Duplication of/in Image · Original Data and/or Images not Provided and/or not Available ·
- Retracted
Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skeletal muscle weight loss is accompanied by small fiber size and low protein content. Alpha-ketoglutarate (AKG) participates in protein and nitrogen metabolism. The effect of AKG on skeletal muscle hypertrophy has not yet been tested, and its underlying mechanism is yet to be determined. In this study, we demonstrated that AKG (2%) increased the gastrocnemius muscle weight and fiber diameter in mice. Our in vitro study also confirmed that AKG dose increased protein synthesis in C2C12 myotubes, which could be effectively blocked by the antagonists of Akt and mTOR. The effects of AKG on skeletal muscle protein synthesis were independent of glutamate, its metabolite. We tested the expression of GPR91 and GPR99. The result demonstrated that C2C12 cells expressed GPR91, which could be upregulated by AKG. GPR91 knockdown abolished the effect of AKG on protein synthesis but failed to inhibit protein degradation. These findings demonstrated that AKG promoted skeletal muscle hypertrophy via Akt/mTOR signaling pathway. In addition, GPR91 might be partially attributed to AKG-induced skeletal muscle protein synthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.