Evidence map›Paper›PMID 27225977›Full record

Trial reportNeurorehabilitation and neural repair2016

Upper-Limb Recovery After Stroke: A Randomized Controlled Trial Comparing EMG-Triggered, Cyclic, and Sensory Electrical Stimulation.

Richard D Wilson, Stephen J Page, Michael Delahanty, Jayme S Knutson, Douglas D Gunzler, Lynne R Sheffler, John Chae

Registry-linked trialOpen access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neurorehabilitation and neural repair, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06527417 (The Effect of Electromyography Triggered Electrical Stimulation on Trunk Balance and Muscle Thickness of Multifidus and Erector Spinae Muscles in Patients With Complete Spinal Cord Injury - A Randomised Controlled Study), which is not on this map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
9.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06527417 nacompletednot on this mapstarted 2023, after this paper: background citation

The Effect of Electromyography Triggered Electrical Stimulation on Trunk Balance and Muscle Thickness of Multifidus and Erector Spinae Muscles in Patients With Complete Spinal Cord Injury - A Randomised Controlled Study

TypeinterventionalSponsorAnkara City Hospital BilkentRan2023 to 2024Enrolled15ConditionsSpinal Cord Injury ThoracicArmsNeuro Trac Myo Plus Pro, Trunk eccentric exercises
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 70 citations in OpenAlex.

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  14. Neurostimulation After Stroke.Physical medicine and rehabilitation clinics of North America · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 1 country.

Richard D WilsonMetroHealth Rehabilitation Institute, MetroHealth Medical Center, Cleveland, OH, USA Case Western Reserve University, Cleveland, OH, USA Cleveland FES Center, Cleveland, OH, USA rwilson@metrohealth.org.
Stephen J PageThe Ohio State University, Columbus, OH, USA.
Michael DelahantyAkron General Medical Center, Akron, OH, USA Northeast Ohio Medical University, Rootstown, OH, USA.
Jayme S KnutsonMetroHealth Rehabilitation Institute, MetroHealth Medical Center, Cleveland, OH, USA Case Western Reserve University, Cleveland, OH, USA Cleveland FES Center, Cleveland, OH, USA.
Douglas D GunzlerCase Western Reserve University, Cleveland, OH, USA.
Lynne R ShefflerMetroHealth Rehabilitation Institute, MetroHealth Medical Center, Cleveland, OH, USA Case Western Reserve University, Cleveland, OH, USA Cleveland FES Center, Cleveland, OH, USA.
John ChaeMetroHealth Rehabilitation Institute, MetroHealth Medical Center, Cleveland, OH, USA Case Western Reserve University, Cleveland, OH, USA Cleveland FES Center, Cleveland, OH, USA.
Cleveland FES Center · USCase Western Reserve University · USMetroHealth · USMetroHealth Medical Center · USNortheast Ohio Medical University · USThe Ohio State University · US

Funding

Electrical stimulation for upper limb recovery in strokeR01HD049777 · NICHD · CASE WESTERN RESERVE UNIVERSITY · PI CHAE, JOHN · 2005 to 2008
$2.2M
NICHD NIH HHS R01 HD049777
6 · The paper itself

Abstract

background and purposeThis study compared the effect of cyclic neuromuscular electrical stimulation (NMES), electromyographically (EMG)-triggered NMES, and sensory stimulation on motor impairment and activity limitations in patients with upper-limb hemiplegia.

methodsThis was a multicenter, single-blind, multiarm parallel-group study of nonhospitalized hemiplegic stroke survivors within 6 months of stroke. A total of 122 individuals were randomized to receive either cyclic NMES, EMG-triggered NMES, or sensory stimulation twice every weekday in 40-minute sessions, over an 8 week-period. Patients were followed for 6 months after treatment concluded.

resultsThere were significant increases in the Fugl-Meyer Assessment [F(1, 111) = 92.6, P < .001], FMA Wrist and Hand [F(1, 111) = 66.7, P < .001], and modified Arm Motor Ability Test [mAMAT; time effect: F(1, 111) = 91.0, P < .001] for all 3 groups. There was no significant difference in the improvement among groups in the FMA [F(2, 384) = 0.2, P = .83], FMA Wrist and Hand [F(2, 384) = 0.4, P = .70], or the mAMAT [F(2, 379) = 1.2, P = .31].

conclusionsAll groups exhibited significant improvement of impairment and functional limitation with electrical stimulation therapy applied within 6 months of stroke. Improvements were likely a result of spontaneous recovery. There was no difference based on the type of electrical stimulation that was administered.

Indexed as

ElectromyographyAdultAgedAged, 80 and overElectric Stimulation TherapyFemaleFollow-Up StudiesHumansMaleMiddle AgedPatient ComplianceRecovery of FunctionSeverity of Illness IndexSingle-Blind MethodStrokeTreatment Outcomeelectrical stimulationfunctionrecoverystroke

Identifiers

PMID27225977
PMCPMC5048487
OpenAlexW2398289100

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.