ReviewJournal of perinatology : official journal of the California Perinatal Association2016
The fetal circulation, pathophysiology of hypoxemic respiratory failure and pulmonary hypertension in neonates, and the role of oxygen therapy.
Review in Journal of perinatology : official journal of the California Perinatal Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Current strategies and opportunities to manufacture cells for modeling human lungs.Advanced drug delivery reviews · 2020Pooled it
- Cardiac lipoma-induced neonatal hypoxemia: a case report underscoring radiological diagnosis and a literature review.Radiology case reports · 2025Article
- Response to Inhaled Nitric Oxide and Mortality Among Very Preterm Neonates With Pulmonary Hypertension.JAMA network open · 2025Observational
- Oxygen saturation targets in neonatal care: A narrative review.Early human development · 2024Review
- Association of Fetal Lung Development Disorders with Adult Diseases: A Comprehensive Review.Journal of personalized medicine · 2024Review
- Assessment of normal pulmonary development using functional magnetic resonance imaging techniques.American journal of obstetrics & gynecology MFM · 2023Article
- [Early risk factors for death in neonates with persistent pulmonary hypertension of the newborn treated with inhaled nitric oxide].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Article
- Care of the critically ill neonate with hypoxemic respiratory failure and acute pulmonary hypertension: framework for practice based on consensus opinion of neonatal hemodynamics working group.Journal of perinatology : official journal of the California Perinatal Association · 2022Review
- Renal biomarkers of acute kidney injury in response to increasing intermittent hypoxia episodes in the neonatal rat.BMC nephrology · 2021Article
- Venovenous versus venoarterial extracorporeal membrane oxygenation among infants with hypoxic-ischemic encephalopathy: is there a difference in outcome?Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Effect of continuous positive airway pressure versus nasal cannula on late preterm and term infants with transient tachypnea of the newborn.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- [Contributing factors for the withdrawal from treatment in neonates with respiratory failure].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021Article
- Perioperative management of arteriovenous malformation guided by integrated evaluation of hemodynamics.European journal of pediatrics · 2021Article
- Asphyxia and Neonatal Respiratory Distress Syndrome Are Independent Predictors of the Non-response to Inhaled Nitric Oxide in the Newborns With PPHN.Frontiers in pediatrics · 2021Article
- Pulmonary Hypertension with Prolonged Patency of the Ductus Arteriosus in Preterm Infants.Children (Basel, Switzerland) · 2020Review
- Antenatal melatonin modulates an enhanced antioxidant/pro-oxidant ratio in pulmonary hypertensive newborn sheep.Redox biology · 2019Article
- Evaluation of Oxygen Saturation Index Compared With Oxygenation Index in Neonates With Hypoxemic Respiratory Failure.JAMA network open · 2019Article
- The Perinatal Asphyxiated Lamb Model: A Model for Newborn Resuscitation.Journal of visualized experiments : JoVE · 2018Article
- Acute hypoxia-reoxygenation and vascular oxygen sensing in the chicken embryo.Physiological reports · 2017Article
- Persistent Pulmonary Hypertension in the Newborn.Children (Basel, Switzerland) · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neonatal hypoxemic respiratory failure (HRF), a deficiency of oxygenation associated with insufficient ventilation, can occur due to a variety of etiologies. HRF can result when pulmonary vascular resistance (PVR) fails to decrease at birth, leading to persistent pulmonary hypertension of newborn (PPHN), or as a result of various lung disorders including congenital abnormalities such as diaphragmatic hernia, and disorders of transition such as respiratory distress syndrome, transient tachypnea of newborn and perinatal asphyxia. PVR changes throughout fetal life, evident by the dynamic changes in pulmonary blood flow at different gestational ages. Pulmonary vascular transition at birth requires an interplay between multiple vasoactive mediators such as nitric oxide, which can be potentially inactivated by superoxide anions. Superoxide anions have a key role in the pathophysiology of HRF. Oxygen (O2) therapy, used in newborns long before our knowledge of the complex nature of HRF and PPHN, has continued to evolve. Over time has come the discovery that too much O2 can be toxic. Recommendations on the optimal inspired O2 levels to initiate resuscitation in term newborns have ranged from 100% (pre 1998) to the currently recommended use of room air (21%). Questions remain about the most effective levels, particularly in preterm and low birth weight newborns. Attaining the appropriate balance between hypoxemia and hyperoxemia, and targeting treatments to the pathophysiology of HRF in each individual newborn are critical factors in the development of improved therapies to optimize outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.