Evidence map›Paper›PMID 27225847›Full record

ArticleJournal of human genetics2016

Additive composite ABCG2, SLC2A9 and SLC22A12 scores of high-risk alleles with alcohol use modulate gout risk.

Hung-Pin Tu, Chia-Min Chung, Albert Min-Shan Ko, Su-Shin Lee, Han-Ming Lai, Chien-Hung Lee, Chung-Ming Huang, Chiu-Shong Liu, Ying-Chin Ko

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In one paragraph

Article in Journal of human genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Hung-Pin TuDepartment of Public Health and Environmental Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chia-Min ChungEnvironment-Omics-Disease Research Center, China Medical University Hospital, Taichung, Taiwan.
Albert Min-Shan KoDepartment of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig Germany.
Su-Shin LeeDivision of Plastic Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Han-Ming LaiDivision of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung, Taiwan.
Chien-Hung LeeDepartment of Public Health, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chung-Ming HuangGraduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan.
Chiu-Shong LiuDepartment of Family Medicine, China Medical University Hospital, Taichung, Taiwan.
Ying-Chin KoEnvironment-Omics-Disease Research Center, China Medical University Hospital, Taichung, Taiwan.
China Medical University · TWKaohsiung Medical University · TWKaohsiung Chang Gung Memorial Hospital · TWMax Planck Institute for Evolutionary Anthropology · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the present study was to evaluate the contribution of urate transporter genes and alcohol use to the risk of gout/tophi. Eight variants of ABCG2, SLC2A9, SLC22A12, SLC22A11 and SLC17A3 were genotyped in male individuals in a case-control study with 157 gout (33% tophi), 106 asymptomatic hyperuricaemia and 295 control subjects from Taiwan. The multilocus profiles of the genetic risk scores for urate gene variants were used to evaluate the risk of asymptomatic hyperuricaemia, gout and tophi. ABCG2 Q141K (T), SLC2A9 rs1014290 (A) and SLC22A12 rs475688 (C) under an additive model and alcohol use independently predicted the risk of gout (respective odds ratio for each factor=2.48, 2.03, 1.95 and 2.48). The additive composite Q141K, rs1014290 and rs475688 scores of high-risk alleles were associated with gout risk (P<0.0001). We observed the supramultiplicative interaction effect of genetic urate scores and alcohol use on gout and tophi risk (P for interaction=0.0452, 0.0033). The synergistic effect of genetic urate score 5-6 and alcohol use indicates that these combined factors correlate with gout and tophi occurrence.

Indexed as

AllelesAdultAgedAge of OnsetAlcohol DrinkingATP Binding Cassette Transporter, Subfamily G, Member 2Case-Control StudiesComorbidityGenotypeGlucose Transport Proteins, FacilitativeGoutHumansHyperuricemiaMaleMiddle AgedOdds RatioATP Binding Cassette Transporter, Subfamily G, Member 2Glucose Transport Proteins, FacilitativeOrganic Anion TransportersOrganic Cation Transport ProteinsSLC22A12 protein, humanSLC2A9 protein, human

Identifiers

PMID27225847
OpenAlexW2395472691

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.