ArticleItalian journal of pediatrics2016
Serological evidence of acute rubella infection among under-fives in Mwanza: a threat to increasing rates of congenital rubella syndrome in Tanzania.
Article in Italian journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 23 citations in OpenAlex.
- Measles and rubella seropositivity among suspected measles cases in northwestern region of Nigeria.Journal of public health in Africa · 2026Article
- A case of congenital rubella syndrome and epidemiology of related cases in China, 2014-2023.Human vaccines & immunotherapeutics · 2024Article
- Article
- The Burden of Likely Rubella Infection among Healthy Pregnant Women in Abakaliki, Ebonyi State, Nigeria.Interdisciplinary perspectives on infectious diseases · 2022Article
- Seroprevalence of IgG Rubella among Infants with Features Suggestive of Congenital Rubella Syndrome at a Tertiary Hospital in North Western Tanzania.The East African health research journal · 2022Article
- Serological Markers of Viral Infections (Rubella Virus, Human Cytomegalovirus and Arboviruses) among Symptomatic Pregnant Women in Rural and Urban Areas of Mwanza, Tanzania.Tropical medicine and infectious disease · 2021Article
- Rubella Eradication: Not Yet Accomplished, but Entirely Feasible.The Journal of infectious diseases · 2021Article
- Rubella seroprevalence using residual samples from the South African measles surveillance program: a cross-sectional analytic study.Human vaccines & immunotherapeutics · 2020Article
- Mother's Knowledge on HIV, Syphilis, Rubella, and Associated Factors in Northern Tanzania: Implications for MTCT Elimination Strategies.International journal of pediatrics · 2020Article
- Rubella virus,African health sciences · 2019Article
- Awareness and Factors Associated with Health Care Worker's Knowledge on Rubella Infection: A Study after the Introduction of Rubella Vaccine in Tanzania.International journal of environmental research and public health · 2019Article
- Risk Factors for Rubella Transmission in Kuyu District, Ethiopia, 2018: A Case-Control Study.Interdisciplinary perspectives on infectious diseases · 2019Article
- Rubella sero-prevalence among children in Kilimanjaro region: a community based study prior to the introduction of rubella vaccine in Tanzania.Italian journal of pediatrics · 2017Article
- Acute Rubella Virus Infection among Women with Spontaneous Abortion in Mwanza City, Tanzania.Journal of clinical and diagnostic research : JCDR · 2017Article
- Incidence of rubella in a state in North-western Nigeria: a call for action.The Pan African medical journal · 2016Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundControl of rubella infection is essential for preventing congenital rubella syndrome (CRS) and one of the important steps is to define a target population for vaccination. Therefore this study was done to determine serological evidence of acute rubella infection among under-fives in order to anticipate the magnitude of rubella virus transmission in Tanzania.
methodsA cross-sectional study involving children aged between 1 and 59 months was conducted between September and October 2014 before national rubella vaccination campaigns commenced. Rubella IgM antibodies were detected using commercial indirect enzyme-linked immunosorbent assay (ELISA). Data were analyzed using STATA version 11.
resultsA total of230 under-fives were enrolled, their median age was 14 (Interquartile range (IQR) 7-26) months. The overall seroprevalence of rubella IgM antibodies was 10.9 % (25/230) with two confirmed cases of CRS. Two-sample Wilcoxon rank-sum test showed that the median age of rubella IgM seropositive children was significantly higher than that of IgM seronegative children (39 IQR: 18-51months vs. 14 IQR: 7-24 months, P < 0.001). On multivariate logistic regression analysis increase in age (OR: 1.07, 95 % CI; 1.03-1.1, P < 0.001) and residing in rural areas (OR: 8.07, 95 % CI; 1.43-45.6, P = 0.018) were independently found to predict acute rubella infection among under-fives.
conclusionOur findings indicate that rubella virus is prevalent in our setting posing a risk of transmitting to childbearing aged women hence increasing the risk of CRS. Increasing prevalence of acute infection with age in under-fives indicates the protective role of maternal antibodies among infants. The sustained vaccination programme of under-fives as effective measure to control CRS should be emphasized in developing countries.
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