Evidence map›Paper›PMID 27225517›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2017

18-kDa translocator protein ligand

Sanna Hellberg, Johanna M U Silvola, Max Kiugel, Heidi Liljenbäck, Nina Savisto, Xiang-Guo Li, Andrea Thiele, Lutz Lehmann, Tobias Heinrich, Sonja Vollmer and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Molecular imaging of atherosclerotic plaque vulnerability: a narrative review.The international journal of cardiovascular imaging · 2026
    Review
  3. Review
  4. Review
  5. Review
  6. Pharmaceutics · 2022
    Review
  7. Review
  8. Review
  9. Positron Emission Tomography in Atherosclerosis Research.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Atherosclerosis Immunoimaging by Positron Emission Tomography.Arteriosclerosis, thrombosis, and vascular biology · 2020
    Review
  18. Current and novel radiopharmaceuticals for imaging cardiovascular inflammation.The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of... · 2020
    Review
  19. PET imaging of macrophages in cardiovascular diseases.American journal of translational research · 2020
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Sanna HellbergTurku PET Centre, University of Turku, Kiinamyllynkatu 4-8, 20520, Turku, Finland.
Johanna M U SilvolaTurku PET Centre, University of Turku, Kiinamyllynkatu 4-8, 20520, Turku, Finland.
Max KiugelTurku PET Centre, University of Turku, Kiinamyllynkatu 4-8, 20520, Turku, Finland.
Heidi LiljenbäckTurku PET Centre, University of Turku, Kiinamyllynkatu 4-8, 20520, Turku, Finland.
Nina SavistoTurku PET Centre, University of Turku, Kiinamyllynkatu 4-8, 20520, Turku, Finland.
Xiang-Guo LiTurku PET Centre, University of Turku, Kiinamyllynkatu 4-8, 20520, Turku, Finland.
Andrea ThieleBayer Pharma AG, Berlin, Germany.
Lutz LehmannBayer Pharma AG, Berlin, Germany.
Tobias HeinrichBayer Pharma AG, Berlin, Germany.
Sonja VollmerBayer Pharma AG, Berlin, Germany.
Harri HakovirtaDepartment of Surgery, University of Turku, Turku, Finland.
V Jukka O LaineDepartment of Pathology, Turku University Hospital, Turku, Finland.
Seppo Ylä-HerttualaA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Juhani KnuutiTurku PET Centre, University of Turku, Kiinamyllynkatu 4-8, 20520, Turku, Finland.
Anne RoivainenTurku PET Centre, University of Turku, Kiinamyllynkatu 4-8, 20520, Turku, Finland.
Antti SarasteTurku PET Centre, University of Turku, Kiinamyllynkatu 4-8, 20520, Turku, Finland. antti.saraste@utu.fi.
University of Turku · FIBayer (Germany) · DETurku University Hospital · FITurku PET Centre · FIUniversity of Eastern Finland · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRadioligands of 18-kDa translocator protein (TSPO) expressed on activated macrophages are a potential approach for imaging of inflammation in atherosclerosis. We evaluated a novel TSPO-targeted tracer METHODS AND

resultsThe distribution kinetics of

conclusions

Indexed as

AnimalsAtherosclerosisBiomarkersHydrocarbons, FluorinatedMetabolic Clearance RateMiceMice, Inbred C57BLMice, KnockoutOrgan SpecificityPyridinesRadiopharmaceuticalsReceptors, GABAReproducibility of ResultsSensitivity and SpecificityTissue Distribution(18F)FEMPABiomarkersBzrp protein, mouseHydrocarbons, FluorinatedPyridinesRadiopharmaceuticalsReceptors, GABA18F-FEMPA18-kDa translocator proteinAtherosclerosisinflammationPET/CT imaging

Identifiers

PMID27225517
OpenAlexW2403806150

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.