ArticleJournal of microbiology (Seoul, Korea)2016
Characteristics of the community-genotype sequence type 72 methicillin-resistant Staphylococcus aureus isolates that underlie their persistence in hospitals.
Article in Journal of microbiology (Seoul, Korea), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Comparing the Phylogenetic Distribution of Multilocus Sequence Typing, Staphylococcal Protein A, and Staphylococcal Cassette Chromosome Mec Types in Methicillin-Resistant Staphylococcus Aureus (MRSA) in Korea from 1994 to 2020.Antibiotics (Basel, Switzerland) · 2023Article
- Dynamics of the MRSA Population in a Chilean Hospital: a Phylogenomic Analysis (2000-2016).Microbiology spectrum · 2023Article
- Performance Evaluation of the IR BiotyperAntibiotics (Basel, Switzerland) · 2022Article
- C-reactive protein predicts persistent bacteremia caused by community-acquired methicillin-resistant Staphylococcus aureus strain.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021Article
- Article
- Changing characteristics of S. aureus bacteremia caused by PVL-negative, MRSA strain over 11 years.Scientific reports · 2021Article
- A Longitudinal Study of Adult Patients withJournal of Korean medical science · 2021Article
- Functional Identification of Serine Hydroxymethyltransferase as a Key Gene Involved in Lysostaphin Resistance and Virulence Potential ofInternational journal of molecular sciences · 2020Article
- Genome-Wide Analysis ofFrontiers in microbiology · 2020Article
- Sterilization efficiency of pathogen-contaminated cottons in a laundry machine.Journal of microbiology (Seoul, Korea) · 2020Article
- NovelAntibiotics (Basel, Switzerland) · 2019Article
- ClinicalToxins · 2019Article
- Impact of Community-Onset Methicillin-ResistantAnnals of laboratory medicine · 2019Article
- Emergence of Community-Genotype Methicillin-Resistant Staphylococcus aureus in Korean Hospitals: Clinical Characteristics of Nosocomial Infections by Community-Genotype Strain.Infection & chemotherapy · 2017Article
- Comparison of subsequent infection in methicillin-resistantAntimicrobial resistance and infection control · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Panton-Valentine leukocidin-negative methicillin-resistant Staphylococcus aureus (MRSA) clone ST72, known as a major community-associated MRSA in Korea, has emerged as an important pathogen in hospitals. To understand bacterial properties that underlie transformation of this clone into a nosocomial pathogen, we compared characteristics of the community-genotype ST72 MRSA isolates with those of ST5 and ST239 MRSA, which have been predominant nosocomial MRSA clones in Korea. Several genes associated with adhesion and virulence were absent or rarely found in ST72 isolates. Many ST72 isolates (70.1%) belonged to agr group I, but the agr group of other ST72 isolates could not be determined. As indicated by d-hemolysin production, ST72 isolates expressed fully functional agr, whereas agr dysfunction was observed in ST5 and ST239 isolates. In the biofilm formation assay, no upregulation of biofilm-forming activity of ST72 MRSA was detected. However, ST72 isolates demonstrated persistence under hypotonic and desiccating conditions (survival rates 72.3% and 33.9%, respectively), which was similar to characteristics of ST5 or ST239 isolates. ST72- MRSA isolates showed low virulence, but properties of their functional agr system could facilitate their spread in hospitals. In conclusion, tolerance to stressful environments, e.g., hypotonic and dry conditions, may also contribute to survival of the community-associated MRSA clones in healthcare facilities.
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