Evidence map›Paper›PMID 27225446›Full record

ArticleBMC cardiovascular disorders2016

Early reduced myocardial diastolic function in children and adolescents with type 1 diabetes mellitus a population-based study.

Leif Brunvand, Drude Fugelseth, Knut Håkon Stensaeth, Knut Dahl-Jørgensen, Hanna Dis Margeirsdottir

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Leif BrunvandDepartment of Pediatrics, Section for Heart Diseases, Oslo University Hospital, Oslo, Norway. leifbrunvand@hotmail.com.
Drude FugelsethDepartment of Neonatal Intensive Care, Oslo University Hospital, Ullevål, Oslo, Norway.
Knut Håkon StensaethDepartment of Radiology and Nuclear medicine, Institute of Circulation and Imaging, Norwegian University of Science and Technology and St Olavs University Hospital, Trondheim, Norway.
Knut Dahl-JørgensenDepartment of Pediatrics, Section for Heart Diseases, Oslo University Hospital, Oslo, Norway.
Hanna Dis MargeirsdottirDepartment of Pediatrics, Akershus University Hospital, Nordbyhagen, Norway.
Oslo University Hospital · NOAkershus University Hospital · NONorwegian University of Science and Technology · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundReduced diastolic myocardial function is an early sign of diabetic cardiomyopathy. The aim of this study was to test the hypothesis that children and adolescents with type 1 diabetes mellitus (T1D), but without other known complications, have early reduced diastolic myocardial function diagnosed with echocardiographic color tissue Doppler imaging (cTDI).

methodscTDI examination was carried out in 173 T1D patients and 62 age-matched controls. The T1D-patients were 8-18 years old with (mean (SD)) diabetes duration of 5.6 (3.4) years and HbA1c of 8.4 (1.3). All were treated with either insulin pumps or 4-6 daily insulin injections. cTDI early (E') and late (A') peak diastolic velocities and systolic peak velocity were measured from the lateral, septal, anterior and posterior mitral annulus and from the lateral tricuspidal annulus.

resultsMyocardial diastolic function was reduced in the T1D-patients with higher peak A'-velocity and lower E'/A'-ratio in all registrations. Overall mean (SD) mitral E'/A'-ratio was 2.3 (0.5) in T1D and 2.7 (0.6) in the controls (p < 0001). The overall mitral E'/A'-ratio was negative associated with blood pressure (BP) and body mass index (BMI). Stratifying all participants into three groups according to BMI (<25, 25-75, >75 centile, respectively), the T1D had lower E'/A'-values in all stratified groups, except for in the highest BMI-group where both T1D and controls had the lowest E'/A'-ratio. Systolic function did not differ in any of the measurements. There were no associations with sex, diabetes duration, carotid artery intima-media-thickness, vessel elasticity or HbA1c.

conclusionDiabetic children and adolescents using modern intensive insulin treatment had echocardiographic signs of reduced diastolic myocardial function despite short duration of disease. The reduced function was associated with higher BP and higher BMI.

Indexed as

Myocardial ContractionVentricular Function, LeftVentricular Function, RightAdolescentAge of OnsetBiomarkersBlood PressureBody Mass IndexChildDiabetes Mellitus, Type 1Diabetic CardiomyopathiesEchocardiography, Doppler, ColorFemaleGlycated HemoglobinHumansHypoglycemic AgentsBiomarkersGlycated Hemoglobinhemoglobin A1c protein, humanHypoglycemic AgentsInsulinBlood pressureBody mass indexDiabetes type-1Diastolic myocardial functionEchocardiographyTissue Doppler imaging

Identifiers

PMID27225446
PMCPMC4881039
OpenAlexW2403137542

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.