ArticleEnvironmental health and preventive medicine2016
Influence of A-21T and C-262T genetic polymorphisms at the promoter region of the catalase (CAT) on gene expression.
Article in Environmental health and preventive medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 36 citations in OpenAlex.
- Article
- The genetic polymorphisms at the promoter region ofMolecular biology research communications · 2023Article
- The rs1001179 SNP and CpG methylation regulate catalase expression in chronic lymphocytic leukemia.Cellular and molecular life sciences : CMLS · 2022Article
- Variability in oxidative stress-related genes (Frontiers in neurology · 2022Article
- The association of CAT-262C/T polymorphism with catalase activity and treatment response in juvenile idiopathic arthritis.Rheumatology international · 2019Article
- Comparison of CAT-21A/T Gene Polymorphism in Women with Preeclampsia and Control Group.Advanced biomedical research · 2018Article
- Genetic polymorphisms of antioxidant enzymes CAT and SOD affect the outcome of clinical, biochemical, and anthropometric variables in people with obesity under a dietary intervention.Genes & nutrition · 2018Article
- Association betweenOncotarget · 2017Article
- Influence of a 50bp Ins/Del polymorphism at promoter of the superoxide dismutase-1 on gene expression and risk of heroin dependency.Environmental health and preventive medicine · 2017Article
- Association of GCLM -588C/T and GCLC -129T/C Promoter Polymorphisms of Genes Coding the Subunits of Glutamate Cysteine Ligase with Ischemic Heart Disease Development in Kazakhstan Population.Disease markers · 2017Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCatalase (CAT, OMIM: 115500) is one of the major antioxidant enzymes, which plays an important role in the clearance of reactive oxygen species. Three genetic polymorphisms of A-21T (rs7943316), C-262T (rs1001179), and C-844T (rs769214) in the promoter region of the CAT have been reported. It has been suggested that these polymorphisms may alter the recognition sites of transcriptional factors, therefore it might be concluded that these polymorphisms may alter the expression levels of the gene. The aim of the present study is to evaluate the associations between these genetic variations and the CAT mRNA levels in human peripheral blood cells.
methodsThe present study consisted of 47 healthy students of Shiraz University (south-west Iran). Genotypes of the CAT polymorphisms were determined by PCR based method. The quantitative CAT mRNA expression levels were investigated using quantitative real-time PCR.
resultsAnalysis of variance revealed significant differences between the study genotypes (For A-21T polymorphism: F = 7.45; df = 2, 44; P = 0.002; For C-262T polymorphism: F = 15.17; df = 2, 44; P < 0.001). The studied polymorphisms showed linkage disequilibrium (D' = 1.0, r
conclusionsThe present findings indicated that these polymorphisms were significantly associated with the gene expression.
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