Evidence map›Paper›PMID 27225074›Full record

ReviewNature reviews. Neuroscience2016

Somatostatin-expressing neurons in cortical networks.

Joanna Urban-Ciecko, Alison L Barth

Open access · greenAbstract readReview
In one paragraph

Review in Nature reviews. Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 214 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
214citing papers in PubMed, 1 pooled it
18.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

214 citing papers in PubMed, 1 synthesis or guideline pooled it, 384 citations in OpenAlex.

  1. Pooled it
  2. Article
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  12. Review
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  16. Article
  17. Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs-cAMP Signaling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  18. Article
  19. Circuit Organization of the Forelimb-Related M2-to-M1 Corticocortical Pathway in the Mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  20. Article

154 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Joanna Urban-CieckoDepartment of Biological Sciences and the Center for the Neural Basis of Cognition, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA.
Alison L BarthDepartment of Biological Sciences and the Center for the Neural Basis of Cognition, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA.
Carnegie Mellon University · USCenter for the Neural Basis of Cognition · US

Funding

High Throughput Approaches for Cell-Specific Synapse CharacterizationRF1MH114103 · NIMH · CARNEGIE-MELLON UNIVERSITY · PI BARTH, ALISON L, BRUCHEZ, MARCEL P · 2017 to 2018
$2.5M
Dynamic connectivity in neocortical networksR01NS088958 · NINDS · CARNEGIE-MELLON UNIVERSITY · PI BARTH, ALISON L · 2016 to 2019
$1.3M
Dynamic connectivity in neocortical networksR56NS088958 · NINDS · CARNEGIE-MELLON UNIVERSITY · PI BARTH, ALISON L · 2015 to 2015
$467k
NIMH NIH HHS RF1 MH114103NINDS NIH HHS R01 NS088958NINDS NIH HHS R56 NS088958
6 · The paper itself

Abstract

Somatostatin-expressing GABAergic neurons constitute a major class of inhibitory neurons in the mammalian cortex and are characterized by dense wiring into the local network and high basal firing activity that persists in the absence of synaptic input. This firing provides both GABA type A receptor (GABAAR)- and GABABR-mediated inhibition that operates at fast and slow timescales. The activity of somatostatin-expressing neurons is regulated by brain state, during learning and in rewarded behaviour. Here, we review recent advances in our understanding of how this class of cells can control network activity, with specific reference to how this is constrained by their anatomical and electrophysiological properties.

Indexed as

Action PotentialsAnimalsgamma-Aminobutyric AcidHumansNeural InhibitionNeuronsReceptors, GABA-ASomatostatingamma-Aminobutyric AcidReceptors, GABA-ASomatostatin

Identifiers

PMID27225074
PMCPMC5635659
OpenAlexW2394842952

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.