ArticleScientific reports2016
Use of recombinant porcine β-defensin 2 as a medicated feed additive for weaned piglets.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Meta-analyses of the global impact of non-antibiotic feed additives on livestock performance and health.Journal of advanced research · 2026Pooled it
- Porcine Beta Defensin 2 Alleviates Apoptosis and Restores Proliferation in IPEC-J2 Cells Challenged with ETEC K88 by Inhibiting the Akt Signaling Pathway.Probiotics and antimicrobial proteins · 2026Article
- Antimicrobial Peptide pBD2 Alleviates Intestinal Damage by Regulating MAPK and Nrf2 Signaling Pathway and Intestinal Microbiota in Mice Challenged with Enterotoxigenic Escherichia Coli K88.Probiotics and antimicrobial proteins · 2026Article
- Antimicrobial Peptides Versus Antibiotics in Farm Animal Production.Antibiotics (Basel, Switzerland) · 2025Review
- The Effects of Recombinant pBD2 on the Growth Performance, Antioxidant Capacity, Immune Function, Intestinal Barrier, and Microbiota of Weaned Piglets.Microorganisms · 2025Article
- Porcine β-Defensin 2 Expressed inAnimals : an open access journal from MDPI · 2025Article
- Expression of recombination antimicrobial protein PIL22-PBD-2 in Pichia pastoris and verification of its biological function in vitro.Veterinary research · 2025Article
- Effects of cecropin antimicrobial peptides on growth and intestinal health in growing male minks.Frontiers in veterinary science · 2025Article
- The Development of New Methods to Stimulate the Production of Antimicrobial Peptides in the Larvae of the Black Soldier FlyInternational journal of molecular sciences · 2023Article
- Porcine intestinal antimicrobial peptide as an in-feed antibiotic alternative improves intestinal digestion and immunity by shaping the gut microbiota in weaned piglets.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2023Article
- Designing a multi-epitope vaccine to control porcine epidemic diarrhea virus infection using immunoinformatics approaches.Frontiers in microbiology · 2023Article
- Recent Progress in the Discovery and Design of Antimicrobial Peptides Using Traditional Machine Learning and Deep Learning.Antibiotics (Basel, Switzerland) · 2022Review
- Antimicrobial peptides: features, applications and the potential use against covid-19.Molecular biology reports · 2022Review
- Review on Preventive Measures to Reduce Post-Weaning Diarrhoea in Piglets.Animals : an open access journal from MDPI · 2022Review
- Multiple roles of ribosomal antimicrobial peptides in tackling global antimicrobial resistance.Royal Society open science · 2022Article
- Effects of Immobilized Antimicrobial Peptides on Growth Performance, Serum Biochemical Index, Inflammatory Factors, Intestinal Morphology, and Microbial Community in Weaning Pigs.Frontiers in immunology · 2022Article
- Reducing the Risk of Transmission of Critical Antimicrobial Resistance Determinants From Contaminated Pork Products to Humans in South-East Asia.Frontiers in microbiology · 2021Review
- Antimicrobial Peptides in Farm Animals: An Updated Review on Its Diversity, Function, Modes of Action and Therapeutic Prospects.Veterinary sciences · 2020Review
- Pigs Overexpressing Porcine β-Defensin 2 Display Increased Resilience toAntibiotics (Basel, Switzerland) · 2020Article
- Generation of Marker-FreeGenes · 2020Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Post-weaning diarrhoea (PWD) in piglets is associated with colonization of the intestine with bacterial pathogens. In this study, we evaluated the use of recombinant porcine β-defensin 2 (rpBD2) as a medicated feed additive for weaned piglets. The crude extract from the culture supernatant of rpBD2-expressing Pichia pastoris was used as a medicated feed additive for weaned piglets. Dietary treatments included a positive control (basal diet + antibiotics, designated PC) and three different rpBD2 treatments without antibiotics (basal diet supplemented with 1, 5, or 15 g of crude rpBD2/kg basal diet, designated 1PD, 5PD, and 15PD, respectively). Of all the treatments, 5PD had the greatest impact on the weaned piglets. It increased their body weight, average daily weight gain, average daily feed intake, and intestinal villus height in the duodenum and jejunum, and reduced the incidence of PWD. The diversity of the cecal digesta and mucosa microflora was compared between the weaned piglets in the PC and 5PD groups. Piglets treated with 5PD had lower diversity indices and fewer bacterial pathogens in their cecal digesta and mucosa than the PC group. Our results demonstrate that crude rpBD2 could provide an alternative to the traditional antibiotic feed additives given to weaned piglets.
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Registered trials
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