Evidence map›Paper›PMID 27224934›Full record

ArticleAnesthesia and analgesia2016

A Novel Device for the Evaluation of Hemostatic Function in Critical Care Settings.

Elisa A Ferrante, Kiev R Blasier, Thomas B Givens, Cynthia A Lloyd, Timothy J Fischer, Francesco Viola

Registry-linked trialAbstract readValidation Study
In one paragraph

Article in Anesthesia and analgesia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03902275 (Validation of a Quantra Supported Hemotherapy Algorithm in Cardiac Surgery), which is not on this map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03902275 naterminatednot on this mapstarted 2019, after this paper: background citation

Validation of a Quantra Supported Hemotherapy Algorithm in Cardiac Surgery

TypeinterventionalSponsorJohann Wolfgang Goethe University HospitalRan2019 to 2020Enrolled20ConditionsHemorrhage, BleedingArmsQuantra-Algorithm, ROTEM-Algorithm
3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. SEER sonorheometry enhances fibrinolysis detection during liver transplantation with heparin.Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis · 2026
    Article
  2. Review
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. The Quantra System: System Description and Protocols for Measurements.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  12. Review
  13. Observational
  14. Review
  15. Review
  16. Observational
  17. Article
  18. Review
  19. Article
  20. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Elisa A FerranteFrom *HemoSonics LLC, Charlottesville, Virginia; and †University of Virginia, Charlottesville, Virginia.
Kiev R Blasier
Thomas B Givens
Cynthia A Lloyd
Timothy J Fischer
Francesco Viola

Funding

Development of a point of care diagnostic to guide efficient usage of blood produR44HL103030 · NHLBI · HEMOSONICS · PI VIOLA, FRANCESCO · 2013 to 2016
$4.2M
Development of a point of care diagnostic to guide efficient usage of blood produR43HL103030 · NHLBI · HEMOSONICS · PI VIOLA, FRANCESCO · 2010 to 2010
$299k
NHLBI NIH HHS R43 HL103030NHLBI NIH HHS R44 HL103030
6 · The paper itself

Abstract

Major surgical procedures often result in significant intra- and postoperative bleeding. The ability to identify the cause of the bleeding has the potential to reduce the transfusion of blood products and improve patient care. We present a novel device, the Quantra Hemostasis Analyzer, which has been designed for automated, rapid, near-patient monitoring of hemostasis. The Quantra is based on Sonic Estimation of Elasticity via Resonance Sonorheometry, a proprietary technology that uses ultrasound to measure clot time and clot stiffness from changes in viscoelastic properties of whole blood during coagulation. We present results of internal validation and analytical performance testing of the technology and demonstrate the ability to characterize the key functional components of hemostasis.

Indexed as

Critical CareHemostasisAutomationBlood CoagulationBlood Coagulation TestsBlood ViscosityCalibrationElastic ModulusEquipment DesignHemorheologyHumansPredictive Value of TestsReference StandardsReproducibility of ResultsRheologyTime Factors

Identifiers

PMID27224934
PMCPMC5536171

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.