Evidence map›Paper›PMID 27224896›Full record

ArticleBirth defects research. Part A, Clinical and molecular teratology2016

Birth defects in infants born to employees of a microelectronics and business machine manufacturing facility.

Sharon R Silver, Lynne E Pinkerton, Carissa M Rocheleau, James A Deddens, Adrian M Michalski, Alissa R Van Zutphen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Birth defects research. Part A, Clinical and molecular teratology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Environmental Contaminants and Congenital Heart Defects: A Re-Evaluation of the Evidence.International journal of environmental research and public health · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sharon R SilverNational Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations and Field Studies, Cincinnati, Ohio.
Lynne E PinkertonNational Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations and Field Studies, Cincinnati, Ohio.
Carissa M RocheleauNational Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations and Field Studies, Cincinnati, Ohio.
James A DeddensNational Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations and Field Studies, Cincinnati, Ohio.
Adrian M MichalskiNew York State Department of Health, Bureau of Environmental and Occupational Epidemiology, Albany, New York.
Alissa R Van ZutphenNew York State Department of Health, Bureau of Environmental and Occupational Epidemiology, Albany, New York.
National Institute for Occupational Safety and Health · USNew York State Department of Health · US

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

backgroundConcerns about solvent releases from a microelectronics/business machine manufacturing facility in upstate New York led to interest in the health of former workers, including this investigation of birth defects in children of male and female employees.

methodsChildren born 1983 to 2001 to facility employees were enumerated and matched to New York State's Congenital Malformations Registry. Reported structural birth defects were compared with numbers expected from state rates (excluding New York City), generating standardized prevalence ratios (SPRs). Exposure assessors classified employees as ever/never potentially exposed at the facility to metals, chlorinated hydrocarbons, and other hydrocarbons during windows critical to organogenesis (female workers) or spermatogenesis (male workers). Among workers, adjusted prevalence ratios were generated to evaluate associations between potential exposures and specific birth defects.

resultsExternal comparisons for structural defects were at expectation for infants of male workers (SPR = 1.01; 95% confidence interval [CI], 0.77-1.29; n = 60) and lower for births to female workers (SPR = 0.84; 95% CI, 0.50-1.33; n = 18). Among full-term infants of male workers, ventricular septal defects (VSDs) were somewhat elevated compared with the general population (SPR = 1.58; 95% CI, 0.99-2.39; n = 22). Within the cohort, potential paternal metal exposure was associated with increased VSD risk (adjusted prevalence ratio = 2.70; 95% CI, = 1.09-6.67; n = 7).

conclusionWhile overall SPRs were near expectation, paternal exposure to metals (primarily lead) appeared to be associated with increased VSD risk in infants. Take-home of occupational exposures, nonoccupational exposures, and chance could not be ruled out as causes. Case numbers for many defects were small, limiting assessment of the role of occupational exposures. Birth Defects Research (Part A) 106:696-707, 2016. © 2016 Wiley Periodicals, Inc.

Indexed as

RegistriesAdultChildFemaleHeart Septal Defects, VentricularHumansHydrocarbons, ChlorinatedIncidenceInfantMaleManufacturing and Industrial FacilitiesMaternal ExposureNew YorkOccupational ExposureOccupationsPaternal ExposureHydrocarbons, ChlorinatedSolventschlorinated hydrocarbonscongenital heart defectsleadmetalsoccupational exposurepaternal exposure

Identifiers

PMID27224896
PMCPMC5577556
OpenAlexW2403271876

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.