Trial reportPloS one2016
Abdominal Obesity, Race and Chronic Kidney Disease in Young Adults: Results from NHANES 1999-2010.
Trial report in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 48 citations in OpenAlex.
- Late-adolescent weight categories and early kidney disease in young adulthood: a nationwide study of Arab and Jewish Israelis.Pediatric nephrology (Berlin, Germany) · 2026Article
- Kidney transplantation in obese Black patients: Strategies to improve access and outcomes.World journal of nephrology · 2026Review
- Obesity-Related Chronic Kidney Disease: From Diagnosis to Treatment.Diagnostics (Basel, Switzerland) · 2025Review
- Venous compression causes chronic cerebral ischaemia in normal pressure hydrocephalus patients.Fluids and barriers of the CNS · 2025Article
- Identification and optimization of relevant factors for chronic kidney disease in abdominal obesity patients by machine learning methods: insights from NHANES 2005-2018.Lipids in health and disease · 2024Article
- Exercise intensity and mortality in overweight and obese patients with chronic kidney disease: longitudinal analysis (1999-2016).BMC public health · 2024Article
- Correlations between oxidative balance score and female asthma among U.S. adults.Scientific reports · 2024Article
- Single-cell transcriptomic analysis reveals transcript enrichment in oxidative phosphorylation, fluid sheer stress, and inflammatory pathways in obesity-related glomerulopathy.Genes & diseases · 2024Article
- Recent Advances in the Management of Diabetic Kidney Disease: Slowing Progression.International journal of molecular sciences · 2024Review
- Development and validation of machine learning models for MASLD: based on multiple potential screening indicators.Frontiers in endocrinology · 2024Article
- Association between dietary vitamin E intake and constipation: NHANES 2005-2010.Frontiers in nutrition · 2024Article
- Reduced kidney function and hypertension in adolescents with low birth weight, NHANES 1999-2016.Pediatric nephrology (Berlin, Germany) · 2023Article
- Diabetic Nephropathy: Update on Pillars of Therapy Slowing Progression.Diabetes care · 2023Review
- Cardiovascular risk and kidney function profiling using conventional and novel biomarkers in young adults: the African-PREDICT study.BMC nephrology · 2023Article
- The Importance of a Healthy Lifestyle in Patients with Congenital Anomalies of Kidney and Urinary Tract.Turkish archives of pediatrics · 2023Article
- Potential link between high FIB-4 score and chronic kidney disease in metabolically healthy men.Scientific reports · 2022Article
- Lifestyle-Related Risk Factors for the Incidence and Progression of Chronic Kidney Disease in the Healthy Young and Middle-Aged Population.Nutrients · 2022Review
- Obesity-related glomerulopathy: Current approaches and future perspectives.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022Review
- Article
- Protocol for the Mason: Health Starts Here prospective cohort study of young adult college students.BMC public health · 2021Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveKidney dysfunction in obesity may be independent of and may precede the development of hypertension and/or diabetes mellitus. We aimed to examine if abdominal obesity is associated with early markers of CKD in a young healthy population and whether these associations differ by race and/or ethnicity.
methodsWe analyzed data from the NHANES 1999-2010 for 6918 young adults ages 20-40 years. Abdominal obesity was defined by gender criteria of waist circumference. CKD markers included estimated glomerular filtration rate and albuminuria ≥30 mg/g. Race stratified analyses were done overall and in subgroups with normal blood pressures, normoglycemia and normal insulin sensitivity. Awareness of CKD was assessed in participants with albuminuria.
resultsAbdominal obesity was present in over one-third of all young adults and was more prevalent among non-Hispanic blacks (45.4%) versus Mexican-Americans (40.6%) or non-Hispanic whites (37.4%) (P-value = 0.004). Mexican-American young adults with abdominal obesity had a higher odds of albuminuria even among those with normal blood pressure, normal glucose, and normal insulin sensitivity [adjusted odds ratio 4.5; 95% confidence interval (1.6-12.2), p = 0.004]. Less than 5% of young adults with albuminuria of all races and ethnicities had been told they had kidney disease.
conclusionAbdominal obesity in young adults, especially in Mexican-Americans, is independently associated with albuminuria even with normal blood pressures, normoglycemia and normal insulin levels. Greater awareness of CKD is needed to protect this young population from long-standing exposure to abdominal obesity and early progressive renal disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.