Evidence map›Paper›PMID 27224454›Full record

ArticleTropical medicine & international health : TM & IH2016

Predictors of early breastfeeding cessation among HIV-infected women in Botswana.

Anthony Ogwu, Sikhulile Moyo, Kathleen Powis, Aida Asmelash, Shahin Lockman, Claire Moffat, Jean Leidner, Joseph Makhema, Max Essex, Roger Shapiro

Open access · bronzeAbstract read
In one paragraph

Article in Tropical medicine & international health : TM & IH, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Anthony OgwuBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Sikhulile MoyoBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Kathleen PowisBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Aida AsmelashBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Shahin LockmanBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Claire MoffatBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Jean LeidnerGoodtables Data Consulting, Norman, OK, USA.
Joseph MakhemaBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Max EssexBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Roger ShapiroBotswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Botswana Harvard AIDS Institute Partnership · BWHarvard University · USBeth Israel Deaconess Medical Center · USBrigham and Women's Hospital · US

Funding

HAART to Prevent HIV Transmission to Infants In BotswanaU01AI066454 · NIAID · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SHAPIRO, ROGER L · 2005 to 2010
$5.3M
Training in HIV Genomics, Treatment, and Cure Research in BotswanaD43TW009610 · FIC · THE BOTSWANA HARVARD HEALTH PARTNERSHIP · PI SHAHIN LOCKMAN, Joseph Moeketsi Makhema · 2013 to 2026
$4.4M
Growth Trends and Mortality Risks Among HIV-exposed Infants in BotswanaK23HD070774 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI POWIS, KATHLEEN · 2012 to 2016
$686k
FIC NIH HHS D43 TW009610NIAID NIH HHS U01 AI066454NICHD NIH HHS K23 HD070774
6 · The paper itself

Abstract

objectiveInfants born to HIV-infected women receiving antiretroviral treatment (ART) can be breastfed through at least 6 months with very low risk of HIV acquisition. We aimed to identify demographic and cultural factors that may influence mothers' willingness to breastfeed for the recommended duration.

methodsWe evaluated factors associated with early cessation of breastfeeding (i.e. before 5 months post-partum) in a randomized clinical trial evaluating different ART regimens used for prevention of mother-to-child transmission during breastfeeding in Botswana. Univariate and multivariable Cox regressions were used to describe predictors of early exclusive BF cessation.

resultsAmong 677 women who started breastfeeding, the median time to breastfeeding cessation was 178 days (IQR 150-181) and 25.1% weaned early. In multivariable analysis, urban location (aHR = 1.86 95%CI 1.27-2.73; P = 0.002), salaried employment or being a student (aHR = 2.78 95% CI 1.63-4.75; P < 0.001) and infant hospitalisation before weaning (aHR = 2.04 95% CI 1.21-3.45; P = 0.008) were independently and significantly associated with early BF cessation.

conclusionsImproved support for breastfeeding among employed mothers, especially in urban settings, may allow HIV-infected women who are receiving ART prophylaxis to breastfeed longer.

Indexed as

allaitement maternelBotswanabreastfeedingHIVlactanciaPMTCTprevención de la transmisión verticalPTMEVIH

Identifiers

PMID27224454
PMCPMC4969096
OpenAlexW2394757409

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.