Evidence map›Paper›PMID 27223670›Full record

ArticleTranscription2016

Super elongation complex contains a TFIIF-related subcomplex.

Bruce A Knutson, Marissa L Smith, Nancy Walker-Kopp, Xia Xu

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transcription, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Bruce A Knutsona Department of Biochemistry and Molecular Biology , SUNY Upstate Medical University , Syracuse , NY , USA.
Marissa L Smitha Department of Biochemistry and Molecular Biology , SUNY Upstate Medical University , Syracuse , NY , USA.
Nancy Walker-Koppa Department of Biochemistry and Molecular Biology , SUNY Upstate Medical University , Syracuse , NY , USA.
Xia Xua Department of Biochemistry and Molecular Biology , SUNY Upstate Medical University , Syracuse , NY , USA.
SUNY Upstate Medical University · US

Funding

Molecular mechanism of RNA polymerase I transcription and dysregulation in cancerK22CA184235 · NCI · UPSTATE MEDICAL UNIVERSITY · PI KNUTSON, BRUCE ALAN · 2014 to 2016
$634k
NCI NIH HHS K22 CA184235
6 · The paper itself

Abstract

Super elongation complex (SEC) belongs to a family of RNA polymerase II (Pol II) elongation factors that has similar properties as TFIIF, a general transcription factor that increases the transcription elongation rate by reducing pausing. Although SEC has TFIIF-like functional properties, it apparently lacks sequence and structural homology. Using HHpred, we find that SEC contains an evolutionarily related TFIIF-like subcomplex. We show that the SEC subunit ELL interacts with the Pol II Rbp2 subunit, as expected for a TFIIF-like factor. These findings suggest a new model for how SEC functions as a Pol II elongation factor and how it suppresses Pol II pausing.

Indexed as

Transcription Elongation, GeneticAmino Acid SequenceHumansModels, BiologicalModels, MolecularMultigene FamilyMultiprotein ComplexesPhylogenyProtein BindingProtein ConformationProtein Interaction Domains and MotifsRNA Polymerase IITranscriptional Elongation FactorsTranscription Factors, TFIIELL2 protein, humanELL protein, humanMultiprotein ComplexesRNA Polymerase IITranscriptional Elongation FactorsTranscription Factors, TFIItranscription factor TFIIFEAFELLelongationpausingSECTFIIF

Identifiers

PMID27223670
PMCPMC4984678
OpenAlexW2397265975

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.