ArticlePhysics in medicine and biology2016
On the computation of a retina resistivity profile for applications in multi-scale modeling of electrical stimulation and absorption.
Article in Physics in medicine and biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Dentate gyrus granule cell activation following extracellular electrical stimulation: a multi-scale computational model to guide hippocampal neurostimulation strategies.Frontiers in computational neuroscience · 2025Article
- Electric field stimulation directs target-specific axon regeneration and partial restoration of vision after optic nerve crush injury.PloS one · 2025Article
- Adaptive octree meshes for simulation of extracellular electrophysiology.Journal of neural engineering · 2023Article
- Impact of Retinal Degeneration on Response of ON and OFF Cone Bipolar Cells to Electrical Stimulation.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2023Article
- Mechanisms underlying activation of retinal bipolar cells through targeted electrical stimulation: a computational study.Journal of neural engineering · 2021Article
- Modeling ON Cone Bipolar Cells for Electrical Stimulation.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2021Article
- Color and cellular selectivity of retinal ganglion cell subtypes through frequency modulation of electrical stimulation.Scientific reports · 2021Article
- Stimulus waveform design for decreasing charge and increasing stimulation selectivity in retinal prostheses.Healthcare technology letters · 2020Article
- Honeycomb-shaped electro-neural interface enables cellular-scale pixels in subretinal prosthesis.Scientific reports · 2019Article
- Model-Based Analysis of Electrode Placement and Pulse Amplitude for Hippocampal Stimulation.IEEE transactions on bio-medical engineering · 2018Article
- Optimization of pillar electrodes in subretinal prosthesis for enhanced proximity to target neurons.Journal of neural engineering · 2018Article
- Increasing Electrical Stimulation Efficacy in Degenerated Retina: Stimulus Waveform Design in a Multiscale Computational Model.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
This study proposes a methodology for computationally estimating resistive properties of tissue in multi-scale computational models, used for studying the interaction of electromagnetic fields with neural tissue, with applications to both dosimetry and neuroprosthetics. Traditionally, models at bulk tissue- and cellular-level scales are solved independently, linking resulting voltage from existing resistive tissue-scale models as extracellular sources to cellular models. This allows for solving the effects that external electric fields have on cellular activity. There are two major limitations to this approach: first, the resistive properties of the tissue need to be chosen, of which there are contradicting measurements in literature; second, the measurements of resistivity themselves may be inaccurate, leading to the mentioned contradicting results found across different studies. Our proposed methodology allows for constructing computed resistivity profiles using knowledge of only the neural morphology within the multi-scale model, resulting in a practical implementation of the effective medium theory; this bypasses concerns regarding the choice of resistive properties and accuracy of measurement setups. A multi-scale model of retina is constructed with an external electrode to serve as a test bench for analyzing existing and resulting resistivity profiles, and validation is presented through the reconstruction of a published resistivity profile of retina tissue. Results include a computed resistivity profile of retina tissue for use with a retina multi-scale model used to analyze effects of external electric fields on neural activity.
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Registered trials
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