Evidence map›Paper›PMID 27223596›Full record

ArticleNeurocase2016

Schizophrenia as a mimic of behavioral variant frontotemporal dementia.

Cora J Kerssens, Welmoed A Krudop, Niels D Prins, Bart N M van Berckel, Annemieke Rozemuller, William W Seeley, Philip Scheltens, Max L Stek, Yolande A L Pijnenburg

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurocase, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Cora J Kerssensa Department of Old Age Psychiatry , GGZ InGeest , Amsterdam , The Netherlands.
Welmoed A Krudopb Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam , VU University Medical Center , Amsterdam , the Netherlands.
Niels D Prinsc Alzheimer Center, Neuroscience Campus Amsterdam , VU University Medical Center , Amsterdam , the Netherlands.
Bart N M van Berckeld Department of Nuclear medicine and PET Research, Neuroscience Campus Amsterdam , VU University Medical Center , Amsterdam , the Netherlands.
Annemieke Rozemullere Department of Neuropathology, Neuroscience Campus Amsterdam , VU University Medical Center , Amsterdam , the Netherlands.
William W Seeleyf Memory and Aging Center, Departments of Neurology and Pathology , University of California , San Francisco , CA , USA.
Philip Scheltensb Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam , VU University Medical Center , Amsterdam , the Netherlands.
Max L Steka Department of Old Age Psychiatry , GGZ InGeest , Amsterdam , The Netherlands.
Yolande A L Pijnenburgb Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam , VU University Medical Center , Amsterdam , the Netherlands.
Amsterdam Neuroscience · NLGGZ inGeest · NLUniversity of California, San Francisco · US

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
NIA NIH HHS P01 AG019724
6 · The paper itself

Abstract

Recently, the diagnostic criteria for the behavioral variant of frontotemporal dementia were revised. Although these criteria offer a relatively high sensitivity, their specificity is yet unknown. We describe a 54-year-old woman fulfilling criteria for both late-onset schizophrenia and probable behavioral variant frontotemporal dementia. Following an initial presentation with psychosis, she developed progressive apathy, compulsiveness, and executive dysfunction. Moreover, bilateral frontotemporal hypometabolism was seen on [(18)F]fludeoxyglucose-positron emission tomography. A post-mortem diagnosis of schizophrenia was established, given the clinical picture combined with the pathological exclusion of a neurodegenerative cause. Our case suggests that patients with other brain disorders may meet the current diagnostic criteria for probable frontotemporal dementia. Further clinicopathological validation of these criteria is needed to determine their exact specificity.

Indexed as

DiagnosisDiagnosis, DifferentialFemaleFrontotemporal DementiaHumansMiddle AgedSchizophreniaFrontotemporal dementiaFTDC criteriaimagingneuropathologyschizophrenia

Identifiers

PMID27223596
PMCPMC5790990
OpenAlexW2395946916

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.