ReviewAlcoholism, clinical and experimental research2016
Habitual Alcohol Seeking: Neural Bases and Possible Relations to Alcohol Use Disorders.
Review in Alcoholism, clinical and experimental research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Etiologic, Theory-Based, Ontogenetic Hierarchical Framework of Alcohol Use Disorder: A Translational Systematic Review of Reviews.Psychological bulletin · 2021Pooled it
- Shifting the balance between goals and habits: Five failures in experimental habit induction.Journal of experimental psychology. General · 2018Trial
- Perceptual response patterns in rhesus macaque attentional set shifting are associated with inflexible behavior.Cognitive, affective & behavioral neuroscience · 2026Article
- FGF21 analogue PF-05231023 on alcohol consumption and neuronal activity in the nucleus accumbens.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Goal-directed behavior and hippocampal activity predict real-life impact of drinking intentions in alcohol use disorder.Translational psychiatry · 2025Article
- When the Mind Cannot Shift: Cognitive Flexibility Impairments in Methamphetamine-Dependent Individuals.Behavioral sciences (Basel, Switzerland) · 2025Article
- Alcohol effects on associative and sensorimotor cortico-thalamo-basal ganglia circuits alter decision making and alcohol intake.Alcohol (Fayetteville, N.Y.) · 2025Review
- Increased alcohol-biased choice behavior in mouse models of high alcohol drinking.Alcohol, clinical & experimental research · 2025Article
- Left Ventral Caudate Functional Connectivity Mediates the Relationship Between Habitual Responding and Alcohol Use.The European journal of neuroscience · 2025Article
- Chronic Ethanol Exposure Produces Persistent Impairment in Cognitive Flexibility and Decision Signals in the Striatum.bioRxiv : the preprint server for biology · 2025Article
- Striatal cell-type specific stability and reorganization underlying agency and habit.bioRxiv : the preprint server for biology · 2025Article
- Editorial: Advances in pharmacotherapy for alcohol use disorder: from mechanisms to clinical interventions.Frontiers in pharmacology · 2025Article
- Cognitive inflexibility moderates the relationship between relief-driven drinking motives and alcohol use.Addictive behaviors reports · 2024Article
- A dual-pathway architecture enables chronic stress to disrupt agency and promote habit formation.bioRxiv : the preprint server for biology · 2024Article
- Article
- Forced Abstinence from Volitional Ethanol Intake Drives a Vulnerable Period of Hyperexcitability in BNST-Projecting Insular Cortex Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Nucleus accumbens and dorsal medial striatal dopamine and neural activity are essential for action sequence performance.The European journal of neuroscience · 2024Article
- A novel inhibitory corticostriatal circuit that expresses mu opioid receptor-mediated synaptic plasticity.Neuropharmacology · 2023Article
- The development of compulsive coping behavior depends on dorsolateral striatum dopamine-dependent mechanisms.Molecular psychiatry · 2023Article
- Elevated Amygdala Responses During De Novo Pavlovian Conditioning in Alcohol Use Disorder Are Associated With Pavlovian-to-Instrumental Transfer and Relapse Latency.Biological psychiatry global open science · 2023Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Loss of flexible control over alcohol use may contribute to the development of alcohol use disorders. An increased contribution of response habits to alcohol-related behaviors may help explain this loss of control. Focusing on data from outcome devaluation and Pavlovian-instrumental transfer procedures, we review evidence for loss of goal-directed control over alcohol seeking and consumption drawing from both preclinical findings and clinical data where they exist. Over the course of extended alcohol self-administration and exposure, the performance of alcohol-seeking responses becomes less sensitive to reduction in the value of alcohol and more vulnerable to the influences of alcohol-predictive stimuli. These behavioral changes are accompanied by a shift in the corticostriatal circuits that control responding from circuits centered on the dorsomedial to those centered on the dorsolateral striatum. These changes in behavioral and neural control could help explain failures to abstain from alcohol despite intention to do so. Understanding and ultimately ameliorating these changes will aid development of more effective treatment interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.