ArticleNutrients2016
Impact of a High-Fat or High-Fiber Diet on Intestinal Microbiota and Metabolic Markers in a Pig Model.
Article in Nutrients, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- The Human Microbiota and Obesity: A Literature Systematic Review of In Vivo Models and Technical Approaches.International journal of molecular sciences · 2018Pooled it
- Modulating the Gut-Microbiota-Brain Axis in Alzheimer's Disease: Therapeutic Potential of Nutritional and Metabolic Factors.CNS neuroscience & therapeutics · 2026Review
- Article
- Dietary Fiber Regulation of Gut Microbiota and Bile Acid Metabolism in Animals: Implications for Animal Nutrition.Veterinary sciences · 2026Review
- Maternal purified fiber supplementation-enriched Akkermansia muciniphila regulates lactation and offspring growth via the gut-mammary axis.Science China. Life sciences · 2026Article
- A review on gut microbiota and miRNA crosstalk: implications for Alzheimer's disease.GeroScience · 2025Review
- Interactive effects among fiber and fat sources on energy and fat digestion in 53- to 74-kg pigs.Journal of animal science · 2025Article
- Effects of fermented bamboo fiber on intestinal health and fecal pollutants in weaned piglets.Frontiers in nutrition · 2025Article
- Cistanche deserticola polysaccharide alleviates constipation by regulating intestinal barrier function and intestinal microbiota and their metabolites.American journal of translational research · 2024Article
- Effect of Dietary Fiber on Reproductive Performance, Intestinal Microorganisms and Immunity of the Sow: A Review.Microorganisms · 2023Review
- Dietary fiber during gestation improves lactational feed intake of sows by modulating gut microbiota.Journal of animal science and biotechnology · 2023Article
- Time-course effects of different fiber-rich ingredients on energy values, microbiota composition and SCFA profile in growing pigs.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2023Article
- Article
- Getting clues from nature: the impact of grass hay on suckling piglets' gastrointestinal growth and colonic microbiota.Frontiers in cellular and infection microbiology · 2023Article
- Microbiota Composition in Diverticular Disease: Implications for Therapy.International journal of molecular sciences · 2022Review
- Postbiotic heat-killed lactobacilli modulates on body weight associated with gut microbiota in a pig model.AMB Express · 2022Article
- Effects of Growth Stage and Rearing Pattern on Pig Gut Microbiota.Current microbiology · 2022Article
- A high-fat and high-fructose diet lowers the cecal digesta's weight and short-chain fatty acid level of a Sprague-Dawley rat model.Turkish journal of medical sciences · 2022Article
- Faecal concentrations of ceftiofur metabolites in finisher pigs administered intramuscularly with ceftiofur.Veterinary medicine and science · 2021Article
- In Vitro Fermentation Characteristics and Fiber-Degrading Enzyme Kinetics of Cellulose, Arabinoxylan,Microorganisms · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To further elaborate interactions between nutrition, gut microbiota and host health, an animal model to simulate changes in microbial composition and activity due to dietary changes similar to those in humans is needed. Therefore, the impact of two different diets on cecal and colonic microbial gene copies and metabolic activity, organ development and biochemical parameters in blood serum was investigated using a pig model. Four pigs were either fed a low-fat/high-fiber (LF), or a high-fat/low-fiber (HF) diet for seven weeks, with both diets being isocaloric. A hypotrophic effect of the HF diet on digestive organs could be observed compared to the LF diet (p < 0.05). Higher gene copy numbers of Bacteroides (p < 0.05) and Enterobacteriaceae (p < 0.001) were present in intestinal contents of HF pigs, bifidobacteria were more abundant in LF pigs (p < 0.05). Concentrations of acetate and butyrate were higher in LF pigs (p < 0.05). Glucose was higher in HF pigs, while glutamic pyruvic transaminase (GPT) showed higher concentrations upon feeding the LF diet (p < 0.001). However, C-reactive protein (CRP) decreased with time in LF pigs (p < 0.05). In part, these findings correspond to those in humans, and are in support of the concept of using the pig as human model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.