Evidence map›Paper›PMID 27223259›Full record

ArticleOncotarget2016

The BRG1 chromatin remodeling enzyme links cancer cell metabolism and proliferation.

Qiong Wu, Pasil Madany, Jason R Dobson, Jake M Schnabl, Soni Sharma, Tara C Smith, Andre J van Wijnen, Janet L Stein, Jane B Lian, Gary S Stein and 3 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.

  1. Pooled it
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  10. The role of SMARCA4 in lung cancer.Scientific reports · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Qiong WuDepartment of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA, USA.
Pasil MadanyDepartment of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA, USA.
Jason R DobsonDepartment of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA, USA.
Jake M SchnablDepartment of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA, USA.
Soni SharmaSchool of Life Sciences, Jawaharlal Nehru University, New Delhi, Delhi, India.
Tara C SmithDepartment of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA, USA.
Andre J van WijnenDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Janet L SteinDepartment of Biochemistry and Vermont Cancer Center for Basic and Translational Research, University of Vermont College of Medicine, Burlington, WA, USA.
Jane B LianDepartment of Biochemistry and Vermont Cancer Center for Basic and Translational Research, University of Vermont College of Medicine, Burlington, WA, USA.
Gary S SteinDepartment of Biochemistry and Vermont Cancer Center for Basic and Translational Research, University of Vermont College of Medicine, Burlington, WA, USA.
Rohini MuthuswamiSchool of Life Sciences, Jawaharlal Nehru University, New Delhi, Delhi, India.
Anthony N ImbalzanoDepartment of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA, USA.
Jeffrey A NickersonDepartment of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA, USA.
University of Massachusetts Chan Medical School · USUniversity of Vermont · USJawaharlal Nehru University · INMayo Clinic in Arizona · US

Funding

SUBNUCLEAR TARGETING OF TRANSCRIPTION FACTORSP01CA082834 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI STEIN, GARY S. · 2001 to 2015
$18.4M
CONTROL OF OSTEOBLAST PROLIFERATION AND DIFFERENTIATIONR01AR039588 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LIAN, JANE B., STEIN, GARY S. · 1990 to 2019
$8.0M
SUBSTRATE RIGIDITY AND GENE EXPRESSION: Role of Nuclear TensionR01EB014869 · NIBIB · UNIVERSITY OF FLORIDA · PI LELE, TANMAY P. · 2012 to 2019
$3.4M
Discovery of BRG1 Inhibitors for Breast Cancer TherapyR21CA185926 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI IMBALZANO, ANTHONY N, NICKERSON, JEFFREY A · 2014 to 2015
$390k
NCI NIH HHS P01 CA082834NCI NIH HHS R21 CA185926NIAMS NIH HHS R01 AR039588NIBIB NIH HHS R01 EB014869
6 · The paper itself

Abstract

Cancer cells reprogram cellular metabolism to meet the demands of growth. Identification of the regulatory machinery that regulates cancer-specific metabolic changes may open new avenues for anti-cancer therapeutics. The epigenetic regulator BRG1 is a catalytic ATPase for some mammalian SWI/SNF chromatin remodeling enzymes. BRG1 is a well-characterized tumor suppressor in some human cancers, but is frequently overexpressed without mutation in other cancers, including breast cancer. Here we demonstrate that BRG1 upregulates de novo lipogenesis and that this is crucial for cancer cell proliferation. Knockdown of BRG1 attenuates lipid synthesis by impairing the transcription of enzymes catalyzing fatty acid and lipid synthesis. Remarkably, exogenous addition of palmitate, the key intermediate in fatty acid synthesis, rescued the cancer cell proliferation defect caused by BRG1 knockdown. Our work suggests that targeting BRG1 to reduce lipid metabolism and, thereby, to reduce proliferation, has promise for epigenetic therapy in triple negative breast cancer.

Indexed as

Breast NeoplasmsCell Line, TumorCell ProliferationChromatinDNA HelicasesFemaleGene Knockdown TechniquesHumansLipidsLipogenesisNuclear ProteinsTranscription FactorsChromatinDNA HelicasesLipidsNuclear ProteinsSMARCA4 protein, humanTranscription Factorsbreast cancerBRG1gene regulationlipogenesismetabolism

Identifiers

PMID27223259
PMCPMC5122388
OpenAlexW2398092487

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.