Trial reportEuropean journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)2017
Lung cancer screening with low-dose spiral computed tomography: evidence from a pooled analysis of two Italian randomized trials.
Trial report in European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02837809 (Early Lung Cancer Detection With Spiral Computed Tomography), which is not on this map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Lung Cancer Detection With Spiral Computed Tomography (CT), Positron Emission Tomography (PET) and Biomarkers: Randomized Trial in High Risk Individuals
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Pooled it
- Lung Cancer Imaging: Screening Result and Nodule Management.International journal of environmental research and public health · 2022Pooled it
- A comparative analysis of heterogeneity in lung cancer screening effectiveness in two randomised controlled trials.Nature communications · 2025Trial
- Prolonged lung cancer screening reduced 10-year mortality in the MILD trial: new confirmation of lung cancer screening efficacy.Annals of oncology : official journal of the European Society for Medical Oncology · 2019Trial
- Impact of deep learning image reconstruction on volumetric accuracy and image quality of pulmonary nodules with different morphologies in low-dose CT.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024Article
- Radiation Exposure to Low-Dose Computed Tomography for Lung Cancer Screening: Should We Be Concerned?Tomography (Ann Arbor, Mich.) · 2023Review
- Endoscopic Technologies for Peripheral Pulmonary Lesions: From Diagnosis to Therapy.Life (Basel, Switzerland) · 2023Review
- Review
- Comprehensive Analysis of Clinical Logistic and Machine Learning-Based Models for the Evaluation of Pulmonary Nodules.JTO clinical and research reports · 2022Article
- Implementation of lung cancer screening: what are the main issues?Translational lung cancer research · 2021Review
- Future directions and management of liquid biopsy in non-small cell lung cancer.Exploration of targeted anti-tumor therapy · 2020Review
- [Lung cancer screening].Der Radiologe · 2019Article
- Look around your target: a new approach to early diagnosis of lung cancer.Annals of translational medicine · 2018Article
- The narrow path to organized LDCT lung cancer screening programs in Europe.Journal of thoracic disease · 2018Review
- Inflammatory status and lung function predict mortality in lung cancer screening participants.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2018Article
- Liquid biopsy for lung cancer early detection.Journal of thoracic disease · 2018Review
- Pulmonary quantitative CT imaging in focal and diffuse disease: current research and clinical applications.The British journal of radiology · 2018Review
- Selecting high-risk individuals for lung cancer screening; the use of risk prediction modelsAnnals of translational medicine · 2017Article
- Five reasons for caution in advocating low-dose computerized tomographic lung cancer screening.Journal of thoracic disease · 2017Article
- Lung cancer screening with low dose CT and radiation harm-from prediction models to cancer incidence data.Annals of translational medicine · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 7 institutions in 2 countries.
Funding
Abstract
The benefits and harms of lung cancer (LC) screening with low-dose computed tomography (LDCT) are debatable. Positive results from the US National Lung Screening Trial were not evident in the European trials, possibly due to their smaller sample sizes. To address this issue, we conducted a patient-level pooled analysis of two Italian randomized controlled trials. Data from DANTE and MILD trials were combined for a total of 3640 individuals in the LDCT arm and 2909 in the control arm. LC and overall mortality were analyzed using multivariate hazard ratios (HRs) and log-rank tests stratified by study. The median follow-up was 8.2 years, with a total of 30 480 person-years in the LDCT arm and 22 157 in the control arm. A total of 192 patients developed LC in the LDCT arm and 105 in the control arm. Half of the LC cases in the LDCT arm had stage IA or IB cancer, as compared with 21% in the control arm. Overall mortality rates/100 000 person-years were 925 in the LDCT arm and 1074 in the control arm, and LC mortality rates were 299 and 357, respectively. The multivariate pooled overall mortality HR was 0.89 (95% confidence interval: 0.74-1.06) and the LC mortality HR was 0.83 (95% confidence interval: 0.61-1.12) for the LDCT arm as compared with the control arm. The present pooled analysis shows a nonsignificant 11% reduction in overall mortality in individuals undergoing LDCT screening as compared with the control arm. A pooled analysis of all European trials would be a useful contribution to assess the real benefit of LDCT screening.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.