ArticleJournal of advanced research2016
In vitro assessment of pharmaceutical potential of ethosomes entrapped with terbinafine hydrochloride.
Article in Journal of advanced research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Improved topical delivery of curcumin by mussel adhesive protein functionalized ethosomes for effective psoriasis treatment.International journal of pharmaceutics: X · 2026Article
- Lipid-based nanocarriers for antifungal drug delivery.Discover nano · 2026Review
- Nanocarriers, Smart Biomaterials and Emerging Therapeutics for Psoriasis: Current Progress and Future Directions.AAPS PharmSciTech · 2026Review
- Development and Characterization of Polymeric Films Loaded with Terbinafine for Fungal Infection Treatment.Polymers · 2025Article
- Development of a Dermal Nanoemulsion with Antioxidants Derived from Rice Residues Using an HLD Theory Approach.AAPS PharmSciTech · 2025Article
- Exploring the Therapeutic Potential of Vesicular Nanocarrier Systems for Elimination of Skin Cancer.Current medicinal chemistry · 2025Review
- Fabrication and assessment of ethosomes for effective transdermal delivery of loxoprofen.Iranian journal of basic medical sciences · 2025Article
- Ethosomes-mediated tryptanthrin delivery as efficient anti-psoriatic nanotherapy by enhancing topical drug absorption and lipid homeostasis.Journal of nanobiotechnology · 2024Article
- Rutin-Loaded Transethosomal Gel for Topical Application: A Comprehensive Analysis of Skin Permeation and Antimicrobial Efficacy.ACS omega · 2024Article
- Polymer Characteristics for Drug Layering on Particles Using a Novel Melt Granulation Technology, MALCOREAAPS PharmSciTech · 2024Article
- Novel Transethosomal Gel Containing Miconazole Nitrate; Development, Characterization, and Enhanced Antifungal Activity.Pharmaceutics · 2023Article
- Statistical optimization of tetrahydrocurcumin loaded solid lipid nanoparticles using Box Behnken design in the management of streptozotocin-induced diabetes mellitus.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023Article
- Design and Characterization of an Ethosomal Gel Encapsulating Rosehip Extract.Gels (Basel, Switzerland) · 2023Article
- Development and Evaluation of Ethosomes Loaded withPharmaceutics · 2022Article
- Therapeutic Textiles Functionalized with Keratin-Based Particles Encapsulating Terbinafine for the Treatment of Onychomycosis.International journal of molecular sciences · 2022Article
- Design, Formulation, and Characterization of Valsartan Nanoethosomes for Improving Their Bioavailability.Pharmaceutics · 2022Article
- Lipid-Based Nanovesicular Drug Delivery Systems.Nanomaterials (Basel, Switzerland) · 2021Review
- Constant Voltage Iontophoresis Technique to Deliver Terbinafine via Transungual Delivery System: Formulation Optimization Using Box-Behnken Design and In Vitro Evaluation.Pharmaceutics · 2021Article
- Ethosomes as Nanocarriers for the Development of Skin Delivery Formulations.Pharmaceutical research · 2021Review
- A Newfangled Collagenase Inhibitor Topical Formulation Based on Ethosomes withPharmaceuticals (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
The present study investigates the entrapment of terbinafine hydrochloride (TH) in ethosomal vesicles via unsonicated and sonication method. Carbopol 934P was incorporated in the best formulation, F6, obtained by sonication method. The formulated ethosomal gel obtained as such i.e. F6(∗) was exploited to achieve a zero order release profile of TH. The composition includes phospholipid, ethanol and propylene glycol. Drug entrapment efficiency (DEE), in-vitro and ex-vivo drug diffusion studies, FT-IR and stability studies of the prepared ethosomes were investigated. The size and shape of F6 ethosomes vesicles were characterized by SEM. In-vitro drug release studies were performed using sigma dialysis membrane in phosphate buffer, pH 7.4 for 12 h while drug content was determined by HPLC. DEE was ranked from 55.33 ± 1.32% to 69.11 ± 2.11%. Highest DEE was seen with F6 ethosomal formulation with a vesicle size of 248 ± 1.02 nm. FT-IR studies confirmed that there was no chemical interaction between drug and excipients used in the formulation. Ex-vivo result suggested that drug diffusion observed after 12 h from F6(∗) and marketed cream (MR) formulations was 74.01 ± 0.62% and 61.45 ± 0.86%, respectively. The results of similarity factor (f 2 values) for MR and F6(∗) ethosomal gel were 85.14 and 42.63, respectively. It revealed that F6(∗) showed dissimilar dissolution profiles. Transdermal flux value for F6(∗) and MR was found to be 144.61 ± 1.28 μg/cm(2)/h and 121.6 ± 1.16 μg/cm(2)/h, respectively. This study disclosed that F6(∗) resides at targeted site for a relatively longer period of time thereby signifying the improved patient compliance.
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