Evidence map›Paper›PMID 27222392›Full record

ArticleDiabetes2016

Unraveling the Paradox of Selective Insulin Resistance in the Liver: the Brain-Liver Connection.

Heather A Ferris, C Ronald Kahn

Abstract readComment
In one paragraph

Article in Diabetes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Multi-Organ Denervation: The Past, Present and Future.Journal of clinical medicine · 2025
    Review
  3. Multi-organ denervation: a novel approach to combat cardiometabolic disease.Hypertension research : official journal of the Japanese Society of Hypertension · 2023
    Review
  4. Article
  5. Article
  6. The regulation of adipocyte growth in white adipose tissue.Frontiers in cell and developmental biology · 2022
    Review
  7. Article
  8. DR-region of NaTheranostics · 2020
    Article
  9. Review
  10. Article
  11. Metabolites as regulators of insulin sensitivity and metabolism.Nature reviews. Molecular cell biology · 2018
    Review
  12. The cell biology of systemic insulin function.The Journal of cell biology · 2018
    Review
  13. Article
  14. Insulin regulation of gluconeogenesis.Annals of the New York Academy of Sciences · 2018
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Heather A FerrisJoslin Diabetes Center, Harvard Medical School, Boston, MA.
C Ronald KahnJoslin Diabetes Center, Harvard Medical School, Boston, MA c.ronald.kahn@joslin.harvard.edu.

Funding

TRAINING IN DIABETES AND METABOLISMT32DK007260 · NIDDK · JOSLIN DIABETES CENTER · PI LAURIE J GOODYEAR · 1986 to 2026
$13.6M
INSULIN RECEPTOR STRUCTURE AND TURNOVERR37DK031036 · NIDDK · JOSLIN DIABETES CENTER · PI KAHN, C RONALD · 2000 to 2019
$12.9M
Insulin Receptor Substrates and Insulin ActionR01DK033201 · NIDDK · JOSLIN DIABETES CENTER · PI KAHN, C RONALD · 1986 to 2016
$10.6M
Insulin and SREBP-2 in brain cholesterol regulationK08DK097293 · NIDDK · UNIVERSITY OF VIRGINIA · PI FERRIS, HEATHER · 2012 to 2016
$752k
Austrian Science Fund FWF P 26766NIDDK NIH HHS K08 DK097293NIDDK NIH HHS R01 DK033201NIDDK NIH HHS R37 DK031036NIDDK NIH HHS T32 DK007260
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Insulin ResistanceLiverBrainHumansInsulinInsulin

Identifiers

PMID27222392
PMCPMC4878421

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.