Trial reportScientific reports2016
Fatigue related impairments in oculomotor control are prevented by caffeine.
Trial report in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Impact of mental and physiological fatigue on attentional focus in basketball players: a systematic review.Frontiers in psychology · 2025Pooled it
- Effects of caffeine ingestion on physiological indexes of human neuromuscular fatigue: A systematic review and meta-analysis.Brain and behavior · 2022Pooled it
- Caffeine increases the velocity of rapid eye movements in unfatigued humans.Psychopharmacology · 2017Trial
- Fatigue-related impairments in oculomotor control are prevented by norepinephrine-dopamine reuptake inhibition.Scientific reports · 2017Trial
- Effect of caffeine on superficial retinal vasculature of the macula in high myopes using optical coherence tomography angiography - A pilot study.Journal of optometryTrial
- Impact of post stroke fatigue on saccadic eye movement control and learning through inflammatory mechanisms.Scientific reports · 2025Article
- Video-based pupillometry using Fourier Mellin image correlation.Scientific reports · 2025Article
- A Review of the Use of Gaze and Pupil Metrics to Assess Mental Workload in Gamified and Simulated Sensorimotor Tasks.Sensors (Basel, Switzerland) · 2024Review
- Curcumin (CUMINUP60®) mitigates exercise fatigue through regulating PI3K/Akt/AMPK/mTOR pathway in mice.Aging · 2023Article
- Diagnosis of colour vision deficits using eye movements.Scientific reports · 2022Article
- Neurorehabilitation in dystonia: a holistic perspective.Journal of neural transmission (Vienna, Austria : 1996) · 2021Review
- Plasma metabolomic profile associated with fatigue in cancer patients.Cancer medicine · 2021Article
- Neuronal adenosine AScientific reports · 2020Article
- Exercise-Induced Fatigue Impairs Bidirectional Corticostriatal Synaptic Plasticity.Frontiers in cellular neuroscience · 2018Article
- Exercise-Induced Fatigue and Caffeine Supplementation Affect Psychomotor Performance but Not Covert Visuo-Spatial Attention.PloS one · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Strenuous exercise can result in an inability of the central nervous system to drive skeletal muscle effectively, a phenomenon known as central fatigue. The impact of central fatigue on the oculomotor system is currently unexplored. Fatigue that originates in the central nervous system may be related to perturbations in the synthesis and metabolism of several neurotransmitters. In this study we examine central fatigue in the oculomotor system after prolonged exercise. The involvement of central neurotransmission was explored by administering caffeine during exercise. Within a double-blind, randomized, repeated measures, crossover design, 11 cyclists consumed a placebo or caffeine solution during 180 min of stationary cycling. Saccadic eye movements were measured using infra-red oculography. Exercise decreased saccade velocity by 8% (placebo trial). This effect was reversed by caffeine, whereby velocity was increased by 11% after exercise. A non-oculomotor perceptual task (global motion processing) was unaffected by exercise. The human oculomotor system is impaired by strenuous exercise of the locomotor system. Caffeine exerts a protective effect on oculomotor control, which could be related to up-regulated central neurotransmission. In addition, cortical processes supporting global motion perception appear to be robust to fatigue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.