Evidence map›Paper›PMID 27222232›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2016

Endometrial BCL6 Overexpression in Eutopic Endometrium of Women With Endometriosis.

Emily Evans-Hoeker, Bruce A Lessey, Jae Wook Jeong, Ricardo F Savaris, Wilder A Palomino, Lingwen Yuan, David P Schammel, Steven L Young

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04107129 (Predicting Endometrial Receptivity for Optimal Reproductive Management), which is not on this map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
10.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04107129 completednot on this mapstarted 2020, after this paper: background citation

Predicting Endometrial Receptivity for Optimal Reproductive Management (PERFORM)

TypeobservationalSponsorStanford UniversityRan2020 to 2024Enrolled76ConditionsInfertility, Female, EndometriosisArmsEndometrial Biopsy, Euploid embryo transfer, Blood sample
3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.

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  20. Endometriosis in the era of precision medicine and impact on sexual and reproductive health across the lifespan and in diverse populations.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Emily Evans-HoekerObstetrics and Gynecology, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA Obstetrics and Gynecology, Carilion Clinic, Virginia Tech Carilion School of Medicine, Roanoke, VA, USA.
Bruce A LesseyObstetrics and Gynecology, Greenville Health System, Greenville, SC, USA.
Jae Wook JeongObstetrics, Gynecology and Reproductive Biology of Michigan State University, Grand Rapids, MI, USA Department of Women's Health, Spectrum Health System, Grand Rapids, MI, USA.
Ricardo F SavarisDepartamento de Ginecologia e Obstetricia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Wilder A PalominoInstitute for Maternal and Child Research, University of Chile, Santiago, Chile.
Lingwen YuanObstetrics and Gynecology, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA.
David P SchammelPathology Associates, Greenville Health System, Greenville, SC, USA.
Steven L YoungObstetrics and Gynecology, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA youngs@med.unc.edu.
University of North Carolina at Chapel Hill · USPrisma Health · USMichigan State University · USUniversidade Federal do Rio Grande do Sul · BRUniversity of Chile · CL

Funding

Tissue Procurement and Cell CultureU54HD040093 · NICHD · UNIVERSITY OF ILLINOIS AT CHICAGO · PI FAZLEABAS, ASGERALLY T. · 2002 to 2011
$13.1M
Progesterone Action in the Endometrium of Women with EndometriosisR01HD067721 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YOUNG, STEVEN L · 2011 to 2015
$3.1M
Steroid Hormone Regulation of Uterine Function and DysfunctionR01HD057873 · NICHD · MICHIGAN STATE UNIVERSITY · PI JEONG, JAE-WOOK · 2008 to 2012
$1.3M
NICHD NIH HHS R01 HD057873NICHD NIH HHS R01 HD067721NICHD NIH HHS U54 HD040093
6 · The paper itself

Abstract

The objective of this study was to examine B-cell CLL/lymphoma 6 (BCL6) expression in human eutopic endometrium across the menstrual cycle in women with and without endometriosis and to establish a cutoff for future studies. This design was a series of case-control studies in tertiary University teaching hospitals. We examined BCL6 expression by messenger RNA and immunohistochemically in prospectively collected samples in both the proliferative (P) and the secretory phases. BCL6 is minimally increased in the mid-secretory phase of the menstrual cycle compared to the P phase in normal patients. BCL6 protein expression was significantly higher in the secretory phase of patients with endometriosis (n = 29) versus fertile controls without endometriosis at laparoscopy (n = 20; P < .0001). Normal fertile controls (n = 28) recruited for endometrial biopsy also had low levels of secretory phase BCL6 expression compared to women with unexplained infertility (UI; n = 119). A receiving-operator characteristic analysis of these data revealed an area under the curve of 94% (95% confidence interval 85%-100%; P < .0001) with an HSCORE cutoff of 1.4 to differentiate cases with and without endometriosis. Using this cutoff value, BCL6 was positive in 88% of cases with UI. Laparoscopic examination of a subset of 65 patients confirmed abnormalities in 98% of cases; 61 (93.8%) were found to have endometriosis, 3 (4.6%) with hydrosalpinx, and 1 (1.5%) with a normal pelvis. These data suggest that BCL6 is a promising candidate as a single diagnostic biomarker for detection of endometriosis in women with otherwise UI and may be associated with endometrial dysfunction, including progesterone resistance.

Indexed as

AdultBiomarkersCase-Control StudiesEndometriosisEndometriumFemaleHumansInfertility, FemaleMenstrual CycleProspective StudiesProto-Oncogene Proteins c-bcl-6RNA, MessengerBCL6 protein, humanBiomarkersProto-Oncogene Proteins c-bcl-6RNA, MessengerBCL6biomarkerendometriosisendometriuminfertility

Identifiers

PMID27222232
PMCPMC5933165
OpenAlexW2401400448

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.