ArticleeLife2016
Regulation of two motor patterns enables the gradual adjustment of locomotion strategy in Caenorhabditis elegans.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Aging-related behavioral defects in Caenorhabditis elegans.Biology open · 2026Article
- NLP-12/Cholecystokinin signaling stabilizes sensory dendritic structure and protects neuronal healthspan inbioRxiv : the preprint server for biology · 2026Article
- Auxin-inducible degradation of UNC-116 in C. elegans inhibits bidirectional dense core vesicle transport and worm locomotion on different timescales.Journal of cell science · 2026Article
- Phenotypic expansion of CALM1/2-associated disorders to include neurologic phenotypes without arrhythmia.Human molecular genetics · 2026Article
- FLP-15 modulates the amplitude of body-bends during locomotion inOpen biology · 2025Article
- Neuroendocrine Control of Synaptic Transmission by PHAC-1 inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Functional analysis of conserved C. elegans bHLH family members uncovers lifespan control by a peptidergic hub neuron.PLoS biology · 2025Article
- Neuropeptide signaling network of Caenorhabditis elegans: from structure to behavior.Genetics · 2024Review
- A Markovian dynamics forProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Functional analysis of conservedbioRxiv : the preprint server for biology · 2024Article
- Antagonism between neuropeptides and monoamines in a distributed circuit for pathogen avoidance.Cell reports · 2024Article
- Article
- Evolutionary conserved peptide and glycoprotein hormone-like neuroendocrine systems in C. elegans.Molecular and cellular endocrinology · 2024Article
- Calcium image analysis in the moving gut.Neurogastroenterology and motility · 2023Article
- The neuropeptidergic connectome of C. elegans.Neuron · 2023Article
- Comparative profiling of cellular gait on adhesive micropatterns defines statistical patterns of activity that underlie native and cancerous cell dynamics.bioRxiv : the preprint server for biology · 2023Article
- Fluctuating landscapes and heavy tails in animal behavior.bioRxiv : the preprint server for biology · 2023Article
- Caenorhabditis elegans foraging patterns follow a simple rule of thumb.Communications biology · 2023Article
- Human calmodulin mutations cause arrhythmia and affect neuronal function in C. elegans.Human molecular genetics · 2023Article
- A proprioceptive feedback circuit drivesProceedings of the National Academy of Sciences of the United States of America · 2023Article
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9 authors.
Funding
Abstract
In animal locomotion a tradeoff exists between stereotypy and flexibility: fast long-distance travelling (LDT) requires coherent regular motions, while local sampling and area-restricted search (ARS) rely on flexible movements. We report here on a posture control system in C. elegans that coordinates these needs. Using quantitative posture analysis we explain worm locomotion as a composite of two modes: regular undulations versus flexible turning. Graded reciprocal regulation of both modes allows animals to flexibly adapt their locomotion strategy under sensory stimulation along a spectrum ranging from LDT to ARS. Using genetics and functional imaging of neural activity we characterize the counteracting interneurons AVK and DVA that utilize FLP-1 and NLP-12 neuropeptides to control both motor modes. Gradual regulation of behaviors via this system is required for spatial navigation during chemotaxis. This work shows how a nervous system controls simple elementary features of posture to generate complex movements for goal-directed locomotion strategies.
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