ArticleScientific reports2016
Identification of heterologous Torque Teno Viruses in humans and swine.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Infectivity of recombinant Torque teno sus virus 1 in pigs coinfected with swine influenza virus.The Journal of general virology · 2026Article
- Article
- First Molecular Detection of Torque Teno Canis Virus in Apparently Healthy Dogs in Southern Italy.Veterinary medicine and science · 2026Article
- Article
- DNA porcine viruses detected on fresh liver samples destined for human consumption.Veterinary research communications · 2025Article
- The mysterious anelloviruses: investigating its role in human diseases.BMC microbiology · 2024Review
- Trans-replicase helper activity of porcine circoviruses promotes the synergistic replication of torque teno virus.Frontiers in microbiology · 2024Article
- Article
- Zoonotic and reverse zoonotic transmission of viruses between humans and pigs.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2021Review
- Torque teno virus from Korean domestic swine farms, 2017-2018.Veterinary medicine and science · 2021Article
- Broad Virus Detection and Variant Discovery in Fecal Samples of Hematopoietic Transplant Recipients Using Targeted Sequence Capture Metagenomics.Frontiers in microbiology · 2020Article
- A new full-length circular DNA sequencing method for viral-sized genomes reveals that RNAi transgenic plants provoke a shift in geminivirus populations in the field.Nucleic acids research · 2019Article
- Possible risks posed by single-stranded DNA viruses of pigs associated with xenotransplantation.Xenotransplantation · 2018Review
- Viromes of one year old infants reveal the impact of birth mode on microbiome diversity.PeerJ · 2018Article
- Detection of a new species of torque teno mini virus from the gingival epithelium of patients with periodontitis.Virus genes · 2017Article
- Transplacental transmission of torque teno virus.Virology journal · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Torque Teno Viruses (TTVs) are ubiquitous viruses which are highly prevalent in several mammalian species. Human TTV's are epidemiologically associated with several human disease conditions such as respiratory illnesses, auto-immune disorders and hepatitis. Recently it was found that swine TTV's (TTSuVs) can act as primary pathogens. The common occurrence of TTVs as environmental contaminants and the increasing interest in the use of swine organs for xenotransplantation lend importance to the question of whether TTV's can cross-infect across species. In this study, we examined human and swine sera by swine or human TTV-specific PCRs, to determine whether swine TTVs (TTSuV) DNA can be detected in humans and vice versa. Surprisingly, both human and TTSuV DNA were present in a majority of the samples tested. Transfection of human PBMC's with TTSuV1 genomic DNA resulted in productive viral infection which was sustained for the three serial passages tested. Lymphoproliferative responses in infected human PBMCs were diminished when compared to the controls. Furthermore, mild to moderate antibody responses against the TTSuV1 ORF2 protein was detected in 16 of the 40 human sera by ELISA. Therefore, these study findings provide initial and fundamental evidence for possible cross-species transmission of TTVs.
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