ArticleMicrobial cell factories2016
GqqA, a novel protein in Komagataeibacter europaeus involved in bacterial quorum quenching and cellulose formation.
Article in Microbial cell factories, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Exploring Genome-Wide Mutation Dynamics and Bacterial Cellulose Impairment inComputational and structural biotechnology journal · 2026Article
- Preparation of Suaeda Tea Through Semi-Solid Fermentation UtilizingBiotech (Basel (Switzerland)) · 2025Article
- Quorum Quenching Approaches against Bacterial-Biofilm-Induced Antibiotic Resistance.Antibiotics (Basel, Switzerland) · 2024Review
- Elevated abundance ofCurrent research in food science · 2024Article
- Exopolysaccharides Producing Bacteria: A Review.Microorganisms · 2023Review
- Characterization of the Putative Acylated Cellulose Synthase Operon inInternational journal of molecular sciences · 2022Article
- Genome analysis suggests the bacterial family Acetobacteraceae is a source of undiscovered specialized metabolites.Antonie van Leeuwenhoek · 2022Article
- The production of bacterial cellulose in Gluconacetobacter xylinus regulated by luxR overexpression of quorum sensing system.Applied microbiology and biotechnology · 2021Article
- The Komagataeibacter europaeus GqqA is the prototype of a novel bifunctional N-Acyl-homoserine lactone acylase with prephenate dehydratase activity.Scientific reports · 2021Article
- Functional and genomic characterization ofBiotechnology reports (Amsterdam, Netherlands) · 2021Article
- Identification of Quorum-Sensing Molecules ofMolecules (Basel, Switzerland) · 2019Article
- Molecular aspects of bacterial nanocellulose biosynthesis.Microbial biotechnology · 2019Review
- Aii810, a Novel Cold-AdaptedFrontiers in microbiology · 2017Article
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4 authors.
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Abstract
backgroundWe report on the functional screening and identification of an active quorum quenching (QQ) gene in the Komagataeibacter europaeus strain CECT 8546, which is a member of the acetic acid bacteria (AAB).
resultsUsing a previously published screening protocol (Schipper et al., in Appl Environ Microbiol 75:224-233, 2009. doi: 10.1128/AEM.01389-08 ) for QQ genes, we identified a single gene, designated gqqA, that interfered strongly with bacterial quorum sensing (QS) in various reporter strains. It encodes for a 281-amino acid protein with a molecular mass of 30 kDa. Although the GqqA protein is similar to predicted prephenate dehydratases, it does not complement Escherichia coli mutants of the pheA gene, thus indicating a potentially different function. Recombinant GqqA protein attenuated QS-dependent pyocyanin production and swarming motility in the Pseudomonas aeruginosa strain PAO1. Moreover, GqqA quenched the QS response of the Agrobacterium tumefaciens NTL4 and the Chromobacterium violaceum CV026 reporter strains. Interestingly, the addition of recombinant GqqA protein to growing cultures of the Komagataeibacter europaeus strain CECT 8546 altered the cellulose production phenotype of CECT 8546 and other AAB strains. In the presence of GqqA protein, cells were planktonic, and no visible cellulose biofilms formed. The addition of low levels of N-acylhomoserine lactones maintained the biofilm formation phenotype.
conclusionsOur data provide evidence for an interconnection between QS and AAB cellulose biofilm formation as well as QQ activity of the GqqA protein.
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