Evidence map›Paper›PMID 27221649›Full record

ArticleObesity (Silver Spring, Md.)2016

Endothelial function following glucose ingestion in adults with prediabetes: Role of exercise intensity.

Steven K Malin, Corey A Rynders, Judy Y Weltman, L Jackson Roberts, Eugene J Barrett, Arthur Weltman

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity (Silver Spring, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03894527 (Impact of Acute Exercise on Vascular Insulin Sensitivity in Metabolic Syndrome), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03894527 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Impact of Acute Exercise on Vascular Insulin Sensitivity in Metabolic Syndrome

TypeinterventionalSponsorUniversity of VirginiaRan2019 to 2020Enrolled16ConditionsMetabolic Syndrome, ObesityArmsSingle Bout of Exercise, Control Condition
3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Exercise and Reduced Nicotine Content Cigarettes in Adult Female Smokers: A Pilot Trial.International journal of environmental research and public health · 2022
    Trial
  3. Trial
  4. Trial
  5. Trial
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Steven K MalinDepartment of Kinesiology, University of Virginia, Charlottesville, Virginia, USA.
Corey A RyndersDivision of Geriatric Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Judy Y WeltmanExercise Physiology Core Laboratory, University of Virginia, Charlottesville, Virginia, USA.
L Jackson RobertsDepartment of Pharmacology and Medicine, Vanderbilt University, Nashville, Tennessee, USA.
Eugene J BarrettDivision of Endocrinology and Metabolism, University of Virginia, Charlottesville, Virginia, USA.
Arthur WeltmanDepartment of Kinesiology, University of Virginia, Charlottesville, Virginia, USA.

Funding

ZACOPRIDE VS METOCLOPRAMIDE--EFFECT ON LOWER ESOPHAGEAL SPHINCTERM01RR000847 · NCRR · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI BRETON, MARC D · 1985 to 2010
$48.1M
NCRR NIH HHS M01 RR000847
6 · The paper itself

Abstract

objectiveTo determine whether high intensity exercise (HIE) would improve endothelial function more than an isocaloric bout of moderate intensity exercise (MIE) following glucose ingestion in adults with prediabetes.

methodsTwelve subjects with prediabetes completed all three conditions: time-course matched control and isocaloric exercise (∼200 kcal) at moderate (MIE; at lactate threshold) and high intensity (HIE; 75% of difference between lactate threshold and VO2 peak). Brachial artery flow-mediated dilation (FMD) was measured before exercise (baseline), within 30 min postexercise, and 1 and 2 hr following a 75 g oral glucose tolerance test (OGTT). Plasma F2-isoprostanes were also assessed during the protocol (i.e., baseline to 2 hr OGTT) as a biomarker of oxidative stress.

resultsMIE reduced postexercise F2-isoprostanesAUC compared with time-course matched control and HIE. Although exercise had no statistical effect on FMD postexercise or during the OGTT, elevations in FMDAUC after MIE and HIE were associated with reduced postexercise F2-isoprostanesAUC .

conclusionsExercise at either intensity had no effect on FMD immediately postexercise following glucose administration. However, individuals with reduced oxidative stress responses to exercise had greater exercise-induced improvement in FMD. Further work is required to identify the mechanism by which exercise alters oxidative stress to enhance endothelial function.

Indexed as

Brachial ArteryEndothelium, VascularExerciseExercise ToleranceF2-IsoprostanesFemaleGlucoseGlucose Tolerance TestHumansMaleMiddle AgedOxidative StressPrediabetic StateSweetening AgentsF2-IsoprostanesGlucoseSweetening Agents

Identifiers

PMID27221649
PMCPMC4925188

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.