ArticleBMC pregnancy and childbirth2016
Impact of vitamin D deficiency on maternal and birth outcomes in the Saudi population: a cross-sectional study.
Article in BMC pregnancy and childbirth, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Vitamin D Levels in Early and Middle Pregnancy and Preeclampsia, a Systematic Review and Meta-Analysis.Nutrients · 2022Pooled it
- Prevalence of Gestational Diabetes Mellitus in the Middle East and North Africa, 2000-2019: A Systematic Review, Meta-Analysis, and Meta-Regression.Frontiers in endocrinology · 2021Pooled it
- Pooled it
- Effects of vitamin D on insulin resistance and fasting blood glucose in pregnant women with insufficient or deficient vitamin D: a randomized, placebo-controlled trial.BMC endocrine disorders · 2022Trial
- Maternal Vitamin D Deficiency and Its Effects on Pregnancy Outcomes.Food science & nutrition · 2026Article
- Maternal Nutrition and Gestational Weight Gain Among Saudi Women: Riyadh Mother and Baby Follow Up Study (RAHMA Explore).Healthcare (Basel, Switzerland) · 2025Article
- Longitudinal changes in vitamin D during twin pregnancy: association with maternal-neonatal outcomes.Frontiers in nutrition · 2025Article
- Association of VDR gene variant rs2228570-Heliyon · 2024Article
- Vitamin D Deficiency and Its Association With Vitamin D Receptor Gene Variants Among Malaysian Women With Hypertensive Disorders in Pregnancy: Protocol for a Nutrigenomics Study.JMIR research protocols · 2024Article
- Seasonal Variations in 25-Hydroxyvitamin D Levels among Pediatric Patients Attending the Healthcare Centre.Nutrients · 2024Article
- Relationship Between Vitamin D Level and Gestational Diabetes Mellitus: A Cross-Sectional Study.Journal of obstetrics and gynaecology of India · 2023Article
- Review
- Vitamin D during pregnancy and its association with birth outcomes: a Brazilian cohort study.European journal of clinical nutrition · 2021Article
- Observational
- Vitamin D Status and Pregnancy Complications: Serum 1,25-di-hydroxyl-Vitamin D and its Ratio to 25-hydroxy-Vitamin D are Superior Biomarkers than 25-hydroxy-Vitamin D.International journal of medical sciences · 2020Observational
- The prevalence of hypovitaminosis D and its risk factors in pregnant women and their newborns in the Middle East: A systematic review.International journal of reproductive biomedicine · 2019Review
- Vitamin D deficiency and depressive symptoms in pregnancy are associated with adverse perinatal outcomes.Journal of behavioral medicine · 2018Article
- Knowledge, attitude and practice of health care practitioners in Saudi Arabia, with regard to prevention of vitamin D deficiency in infancy.Saudi medical journal · 2018Article
- Maternal vitamin D deficiency increases the risk of adverse neonatal outcomes in the Chinese population: A prospective cohort study.PloS one · 2018Article
- Vitamin D status correction in Saudi Arabia: an experts' consensus under the auspices of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis, and Musculoskeletal Diseases (ESCEO).Archives of osteoporosis · 2017Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLow serum vitamin D [25(OH)D] has been associated with different health problems worldwide. However, its causal role in several diseases remains unclear. We aimed to correlate vitamin D status with maternal and neonatal outcomes in pregnant females.
methodOne thousand pregnant women were recruited during early labour from the labour ward of King Khaled University Hospital, Riyadh, Saudi Arabia. Detailed medical data of all participants were collected from their records. Delivery events and birth outcomes were also documented. Serum 25(OH)D levels were measured using an enzyme-linked immunosorbent assay. A receiver operating characteristic (ROC) curve was constructed to evaluate the ability of vitamin D levels to predict complicated pregnancies. Regression analysis was used to test the correlation between serum 25(OH)D levels and different variables.
resultsMost of the participants were Saudis (89.9 %) and housewives (85.1 %) and 86.4 % of them had vitamin D deficiency (mean: 30.46 ± 19.6 nmol/L). Gestational diabetes mellitus (GDM) was the commonest complication detected (11.1 %) while the history of miscarriage was elevated (24.5 %). There was no association between GDM and low 25(OH)D. Yet, there was a significant negative correlation between serum 25(OH)D levels and fasting blood glucose among females older than 35 years (r = -0.2, p = 0.03). Hypertensive disorders of pregnancy and pre-existing hypertension were less than 1.5 % of frequency. Nevertheless, they were only recorded in women with insufficient and deficient vitamin D. ROC curve revealed that 25(OH)D levels were not able to discriminate between normal and adverse pregnancy outcomes (AUROC curve: 0.51; 95 % confidence interval (CI): 0.44-0.58; p = 0.8).
conclusionHypovitaminosis D, a highly prevalent health problem among pregnant females in Riyadh, has no relation to adverse pregnancy outcomes except for a higher prevalence of miscarriage in women with low 25(OH)D.
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