Evidence map›Paper›PMID 27221611›Full record

ReviewJournal of dental research2016

The Contributions of the Ribosome Biogenesis Protein Utp5/WDR43 to Craniofacial Development.

S B Sondalle, S J Baserga, P C Yelick

Open access · greenAbstract readReview
In one paragraph

Review in Journal of dental research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.2field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

S B SondalleDepartment of Genetics, Yale University School of Medicine, New Haven, CT, USA.
S J BasergaDepartment of Genetics, Yale University School of Medicine, New Haven, CT, USA Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT, USA Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA.
P C YelickDepartment of Orthodontics, Division of Craniofacial and Molecular Genetics, Tufts University, Boston, MA, USA pamela.yelick@tufts.edu.
Yale University · USTufts University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9M
GENETICS AND GENOMICS OF HUMAN DISEASET32HD007149 · NICHD · YALE UNIVERSITY · PI James P Noonan · 1985 to 2026
$8.2M
Key factors in human ribosome biogenesisR01GM115710 · NIGMS · YALE UNIVERSITY · PI BASERGA, SUSAN J · 2015 to 2018
$1.6M
NOVEL SCREEN FOR MINERALIZED CRANIOFACIAL AND TOOTH MUTANTS IN ZEBRAFISHR01DE018043 · NIDCR · TUFTS UNIVERSITY BOSTON · PI YELICK, PAMELA C · 2007 to 2009
$1.2M
Probing the Pathogenesis of North American Indian Childhood Cirrhosis (NAIC)F30DK109582 · NIDDK · YALE UNIVERSITY · PI SONDALLE, SAMUEL BRADY · 2016 to 2017
$57k
NICHD NIH HHS T32 HD007149NIDCR NIH HHS R01 DE018043NIDDK NIH HHS F30 DK109582NIGMS NIH HHS R01 GM115710NIGMS NIH HHS T32 GM007205
6 · The paper itself

Abstract

Fairly recently, it was recognized that human ribosomopathies-developmental defects caused by mutations in ribosome biogenesis proteins-can exhibit tissue-specific defects rather than the expected global defects. This apparent anomaly-that seemingly ubiquitously expressed and required ribosomal proteins can have distinct functions in cell and tissue differentiation-has spurred new areas of research focused on better understanding translational mechanisms, biogenesis, and function in diverse cell types. This renewed appreciation for, and need to better understand, roles for ribosomal proteins in human development and disease has identified surprising similarities and differences in a variety of human ribosomopathies. Here, we discuss ribosomal protein functions in health and disease, focusing on the ribosome biogenesis protein Utp5/WDR43. New and exciting research in this field is anticipated to provide insight into a variety of previously understudied craniofacial dysostoses and result in significantly improved knowledge and understanding of roles for translational machinery in human craniofacial development and disease.

Indexed as

AnimalsCraniofacial AbnormalitiesFacial BonesHumansIntercellular Signaling Peptides and ProteinsNuclear ProteinsRibosomal ProteinsRibosomesSkullZebrafish ProteinsIntercellular Signaling Peptides and ProteinsNuclear ProteinsRibosomal ProteinsWdr43 protein, zebrafishZebrafish Proteinscell biologycraniofacial anomaliescraniofacial biology/geneticsdevelopmental biologygeneticszebrafish

Identifiers

PMID27221611
PMCPMC5076753
OpenAlexW2406618565

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.