Evidence map›Paper›PMID 27221597›Full record

ArticleJournal of the International Neuropsychological Society : JINS2016

Visual Perceptual Organization Ability in Autopsy-Verified Dementia with Lewy Bodies and Alzheimer's Disease.

Micaela Mitolo, Joanne M Hamilton, Kelly M Landy, Lawrence A Hansen, Douglas Galasko, Francesca Pazzaglia, David P Salmon

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the International Neuropsychological Society : JINS, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Visual dysfunction in dementia with Lewy bodies.Current neurology and neuroscience reports · 2024
    Review
  2. Review
  3. Prediction of neuropathologic lesions from clinical data.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Genome-Wide Profiling of miRNA and mRNA Expression in Alzheimer's Disease.Medical science monitor : international medical journal of experimental and clinical research · 2017
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Micaela Mitolo1Fondazione San Camillo Ospedale - IRCCS,Venice,Italy.
Joanne M Hamilton2Department of Neurosciences,University of California San Diego,San Diego,California.
Kelly M Landy2Department of Neurosciences,University of California San Diego,San Diego,California.
Lawrence A Hansen2Department of Neurosciences,University of California San Diego,San Diego,California.
Douglas Galasko2Department of Neurosciences,University of California San Diego,San Diego,California.
Francesca Pazzaglia6Department of Psychology,University of Padua,Padua,Italy.
David P Salmon2Department of Neurosciences,University of California San Diego,San Diego,California.
University of California, San Diego · USOspedale generale di zona San Camillo Treviso · ITSan Francisco VA Medical Center · USUniversity of Padua · IT

Funding

VIRUS-INDUCED BRAIN PATHOLOGYP50AG005131 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GALASKO, DOUGLAS R · 1985 to 2018
$55.4M
COGNITIVE STUDIES OF THE LEWY BODY VARIANT OF ADR01AG012963 · NIA · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI SALMON, DAVID P · 1994 to 2005
$1.0M
NIA NIH HHS P50 AG005131NIA NIH HHS R01 AG012963
6 · The paper itself

Abstract

objectivesProminent impairment of visuospatial processing is a feature of dementia with Lewy bodies (DLB), and diagnosis of this impairment may help clinically distinguish DLB from Alzheimer's disease (AD). The current study compared autopsy-confirmed DLB and AD patients on the Hooper Visual Organization Test (VOT), a test that requires perceptual and mental reorganization of parts of an object into an identifiable whole. The VOT may be particularly sensitive to DLB since it involves integration of visual information processed in separate dorsal and ventral visual "streams".

methodsDemographically similar DLB (n=28), AD (n=115), and normal control (NC; n=85) participants were compared on the VOT and additional neuropsychological tests. Patient groups did not differ in dementia severity at time of VOT testing. High and Low AD-Braak stage DLB subgroups were compared to examine the influence of concomitant AD pathology on VOT performance.

resultsBoth patient groups were impaired compared to NC participants. VOT scores of DLB patients were significantly lower than those of AD patients. The diagnostic sensitivity and specificity of the VOT for patients versus controls was good, but marginal for DLB versus AD. High-Braak and low-Braak DLB patients did not differ on the VOT, but High-Braak DLB performed worse than Low-Braak DLB on tests of episodic memory and language.

conclusionsVisual perceptual organization ability is more impaired in DLB than AD but not strongly diagnostic. The disproportionate severity of this visual perceptual deficit in DLB is not related to degree of concomitant AD pathology, which suggests that it might primarily reflect Lewy body pathology. (JINS, 2016, 22, 609-619).

Indexed as

AgedAged, 80 and overAlzheimer DiseaseAutopsyHumansLewy Body DiseaseNeuropsychological TestsVisual PerceptionAlzheimer’s diseaseDementiaDementia with Lewy BodiesVisual organizationVisuoperceptual deficitVisuospatial deficit

Identifiers

PMID27221597
PMCPMC5802394
OpenAlexW2404731563

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.