ReviewTranslational stroke research2016
Improving Reperfusion Therapies in the Era of Mechanical Thrombectomy.
Review in Translational stroke research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and Safety of NaoShuanTong Capsule in the Treatment of Ischemic Stroke: A Meta-Analysis.Frontiers in pharmacology · 2019Pooled it
- Cellular Mechanisms Underlying Endothelial and Histopathological Alterations Induced by Cerebral Angiography.Journal of clinical medicine · 2026Review
- Dynamic CTA-Based Whole-Brain Arterial-Venous Collateral Assessment for Predicting Futile Recanalization in Acute Ischemic Stroke.Aging and disease · 2025Article
- Impact of NA-1 on Pericyte-Driven Vasoconstriction and Its Role in No-Reflow During Cerebral Ischemia-Reperfusion.CNS neuroscience & therapeutics · 2025Article
- Microglia and Macrophages in Neuroprotection, Neurogenesis, and Emerging Therapies for Stroke.Cells · 2021Review
- Review
- Absent filling of the superficial middle cerebral vein is associated with reperfusion but not parenchymal hematoma in stroke patients undergoing thrombectomy: an observational study.Annals of translational medicine · 2020Article
- Small extracellular vesicles secreted by human iPSC-derived MSC enhance angiogenesis through inhibiting STAT3-dependent autophagy in ischemic stroke.Stem cell research & therapy · 2020Article
- Pericytes in Microvessels: From "Mural" Function to Brain and Retina Regeneration.International journal of molecular sciences · 2019Review
- Endovascular equipoise shift in a phase III randomized clinical trial of sonothrombolysis for acute ischemic stroke.Therapeutic advances in neurological disorders · 2019Article
- Angiographical Identification of Intracranial, Atherosclerosis-Related, Large Vessel Occlusion in Endovascular Treatment.Frontiers in neurology · 2019Review
- Development of a Routinely Applicable Imaging Protocol for Fast and Precise Middle Cerebral Artery Occlusion Assessment and Perfusion Deficit Measure in an Ovine Stroke Model: A Case Study.Frontiers in neurology · 2019Article
- Clinical outcome prediction after thrombectomy of proximal middle cerebral artery occlusions by the appearance of lenticulostriate arteries on magnetic resonance angiography: A retrospective analysis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Article
- Mapping the collaterome for precision cerebrovascular health: Theranostics in the continuum of stroke and dementia.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Review
- Spatiotemporal Protein Atlas of Cell Death-Related Molecules in the Rat MCAO Stroke Model.Experimental neurobiology · 2018Article
- Cell-based and pharmacological neurorestorative therapies for ischemic stroke.Neuropharmacology · 2018Review
- Transcervical access via direct neck exposure for neurointerventional procedures in the hybrid angiosuite.Neuroradiology · 2018Article
- Delayed Recanalization Promotes Functional Recovery in Rats Following Permanent Middle Cerebral Artery Occlusion.Translational stroke research · 2018Article
- To Improve Translational Research in Subarachnoid Hemorrhage.Translational stroke research · 2018Article
- Translational Stroke Research Guideline Projections: The 20/20 Standards.Translational stroke research · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Recent positive clinical trials using mechanical thrombectomy proved that endovascular recanalization is an effective treatment for patients with acute stroke secondary to large vessel occlusions. The trials offer definite evidence that in acute ischemia recanalization is a powerful predictor of good outcome. However, even in the era of rapid and effective recanalization using endovascular approaches, the percentage of patients with good outcomes varies between 33 and 71 %. In addition, the number of patients who are eligible for endovascular thrombectomy is small and usually based on having salvageable tissue on imaging. There is therefore room for improvement to both enhance the effectiveness of current practice and expand treatment to a larger subset of stroke patients. In this review, we highlight some of the most promising approaches to improve endovascular therapy by combining with strategies to enhance collateral perfusion and vascular protection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.